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Literature summary extracted from

  • Davies, B.W.; Bogard, R.W.; Young, T.S.; Mekalanos, J.J.
    Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence (2012), Cell, 149, 358-370.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.7.B24 D131A/D133A loss of catalytic activity Vibrio cholerae O1

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.B24 additional information Vibrio cholerae O1 in cytosolic samples from a Vibrio cholerae DncV deletion strain expressing wild-type DncV, only product cyclic Ap(3'-5')G is found, not cyclic Gp(3'-5')G or cyclic Ap(3'-5')A ?
-
 ?
2.7.7.B24 additional information Vibrio cholerae O1 ATCC 39315 in cytosolic samples from a Vibrio cholerae DncV deletion strain expressing wild-type DncV, only product cyclic Ap(3'-5')G is found, not cyclic Gp(3'-5')G or cyclic Ap(3'-5')A ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.B24 Vibrio cholerae O1 Q9KVG7
-
-
2.7.7.B24 Vibrio cholerae O1 ATCC 39315 Q9KVG7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.B24 ATP + ATP
-
 Vibrio cholerae O1 2 diphosphate + cyclic Ap(3'-5')Ap
-
 ?
2.7.7.B24 ATP + ATP
-
 Vibrio cholerae O1 ATCC 39315 2 diphosphate + cyclic Ap(3'-5')Ap
-
 ?
2.7.7.B24 ATP + GTP DncV preferentially synthesizes a hybrid c-AMP-GMP molecule from ATP and GTP Vibrio cholerae O1 2 diphosphate + cyclic Ap(3'-5')Gp
-
 ?
2.7.7.B24 ATP + GTP DncV preferentially synthesizes a hybrid c-AMP-GMP molecule from ATP and GTP Vibrio cholerae O1 ATCC 39315 2 diphosphate + cyclic Ap(3'-5')Gp
-
 ?
2.7.7.B24 GTP + GTP
-
 Vibrio cholerae O1 2 diphosphate + cyclic Gp(3'-5')G
-
 ?
2.7.7.B24 GTP + GTP
-
 Vibrio cholerae O1 ATCC 39315 2 diphosphate + cyclic Gp(3'-5')G
-
 ?
2.7.7.B24 additional information in cytosolic samples from a Vibrio cholerae DncV deletion strain expressing wild-type DncV, only product cyclic Ap(3'-5')G is found, not cyclic Gp(3'-5')G or cyclic Ap(3'-5')A Vibrio cholerae O1 ?
-
 ?
2.7.7.B24 additional information no activity with TTP, UTP and CTP Vibrio cholerae O1 ?
-
 ?
2.7.7.B24 additional information in cytosolic samples from a Vibrio cholerae DncV deletion strain expressing wild-type DncV, only product cyclic Ap(3'-5')G is found, not cyclic Gp(3'-5')G or cyclic Ap(3'-5')A Vibrio cholerae O1 ATCC 39315 ?
-
 ?
2.7.7.B24 additional information no activity with TTP, UTP and CTP Vibrio cholerae O1 ATCC 39315 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.B24 di-nucleotide cyclase Vibrio
-
 Vibrio cholerae O1
2.7.7.B24 VC0179
-
 Vibrio cholerae O1

General Information

EC Number General Information Comment Organism
2.7.7.B24 physiological function disruption of the DncV gene causes a significant defect in intestinal colonization by Vibrio cholerae. Increased expression of DncV severely inhibits Vibrio cholerae chemotaxis, expression of DncV does not change overall motility Vibrio cholerae O1