BRENDA - Enzyme Database

Coordinated regulation of accessory genetic elements produces cyclic di-nucleotides for V. cholerae virulence

Davies, B.W.; Bogard, R.W.; Young, T.S.; Mekalanos, J.J.; Cell 149, 358-370 (2012)

Data extracted from this reference:

Engineering
EC Number
Protein Variants
Commentary
Organism
2.7.7.B24
D131A/D133A
loss of catalytic activity
Vibrio cholerae O1
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
2.7.7.B24
additional information
Vibrio cholerae O1
in cytosolic samples from a Vibrio cholerae DncV deletion strain expressing wild-type DncV, only product cyclic Ap(3'-5')G is found, not cyclic Gp(3'-5')G or cyclic Ap(3'-5')A
?
-
-
?
2.7.7.B24
additional information
Vibrio cholerae O1 ATCC 39315
in cytosolic samples from a Vibrio cholerae DncV deletion strain expressing wild-type DncV, only product cyclic Ap(3'-5')G is found, not cyclic Gp(3'-5')G or cyclic Ap(3'-5')A
?
-
-
?
Organism
EC Number
Organism
UniProt
Commentary
Textmining
2.7.7.B24
Vibrio cholerae O1
Q9KVG7
-
-
2.7.7.B24
Vibrio cholerae O1 ATCC 39315
Q9KVG7
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
2.7.7.B24
ATP + ATP
-
740285
Vibrio cholerae O1
2 diphosphate + cyclic Ap(3'-5')A
-
-
-
?
2.7.7.B24
ATP + ATP
-
740285
Vibrio cholerae O1 ATCC 39315
2 diphosphate + cyclic Ap(3'-5')A
-
-
-
?
2.7.7.B24
ATP + GTP
DncV preferentially synthesizes a hybrid c-AMP-GMP molecule from ATP and GTP
740285
Vibrio cholerae O1
2 diphosphate + cyclic Ap(3'-5')G
-
-
-
?
2.7.7.B24
ATP + GTP
DncV preferentially synthesizes a hybrid c-AMP-GMP molecule from ATP and GTP
740285
Vibrio cholerae O1 ATCC 39315
2 diphosphate + cyclic Ap(3'-5')G
-
-
-
?
2.7.7.B24
GTP + GTP
-
740285
Vibrio cholerae O1
2 diphosphate + cyclic Gp(3'-5')G
-
-
-
?
2.7.7.B24
GTP + GTP
-
740285
Vibrio cholerae O1 ATCC 39315
2 diphosphate + cyclic Gp(3'-5')G
-
-
-
?
2.7.7.B24
additional information
in cytosolic samples from a Vibrio cholerae DncV deletion strain expressing wild-type DncV, only product cyclic Ap(3'-5')G is found, not cyclic Gp(3'-5')G or cyclic Ap(3'-5')A
740285
Vibrio cholerae O1
?
-
-
-
?
2.7.7.B24
additional information
no activity with TTP, UTP and CTP
740285
Vibrio cholerae O1
?
-
-
-
?
2.7.7.B24
additional information
in cytosolic samples from a Vibrio cholerae DncV deletion strain expressing wild-type DncV, only product cyclic Ap(3'-5')G is found, not cyclic Gp(3'-5')G or cyclic Ap(3'-5')A
740285
Vibrio cholerae O1 ATCC 39315
?
-
-
-
?
2.7.7.B24
additional information
no activity with TTP, UTP and CTP
740285
Vibrio cholerae O1 ATCC 39315
?
-
-
-
?
Synonyms
EC Number
Synonyms
Commentary
Organism
2.7.7.B24
di-nucleotide cyclase Vibrio
-
Vibrio cholerae O1
2.7.7.B24
VC0179
-
Vibrio cholerae O1
Engineering (protein specific)
EC Number
Protein Variants
Commentary
Organism
2.7.7.B24
D131A/D133A
loss of catalytic activity
Vibrio cholerae O1
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
2.7.7.B24
additional information
Vibrio cholerae O1
in cytosolic samples from a Vibrio cholerae DncV deletion strain expressing wild-type DncV, only product cyclic Ap(3'-5')G is found, not cyclic Gp(3'-5')G or cyclic Ap(3'-5')A
?
-
-
?
2.7.7.B24
additional information
Vibrio cholerae O1 ATCC 39315
in cytosolic samples from a Vibrio cholerae DncV deletion strain expressing wild-type DncV, only product cyclic Ap(3'-5')G is found, not cyclic Gp(3'-5')G or cyclic Ap(3'-5')A
?
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
2.7.7.B24
ATP + ATP
-
740285
Vibrio cholerae O1
2 diphosphate + cyclic Ap(3'-5')A
-
-
-
?
2.7.7.B24
ATP + ATP
-
740285
Vibrio cholerae O1 ATCC 39315
2 diphosphate + cyclic Ap(3'-5')A
-
-
-
?
2.7.7.B24
ATP + GTP
DncV preferentially synthesizes a hybrid c-AMP-GMP molecule from ATP and GTP
740285
Vibrio cholerae O1
2 diphosphate + cyclic Ap(3'-5')G
-
-
-
?
2.7.7.B24
ATP + GTP
DncV preferentially synthesizes a hybrid c-AMP-GMP molecule from ATP and GTP
740285
Vibrio cholerae O1 ATCC 39315
2 diphosphate + cyclic Ap(3'-5')G
-
-
-
?
2.7.7.B24
GTP + GTP
-
740285
Vibrio cholerae O1
2 diphosphate + cyclic Gp(3'-5')G
-
-
-
?
2.7.7.B24
GTP + GTP
-
740285
Vibrio cholerae O1 ATCC 39315
2 diphosphate + cyclic Gp(3'-5')G
-
-
-
?
2.7.7.B24
additional information
in cytosolic samples from a Vibrio cholerae DncV deletion strain expressing wild-type DncV, only product cyclic Ap(3'-5')G is found, not cyclic Gp(3'-5')G or cyclic Ap(3'-5')A
740285
Vibrio cholerae O1
?
-
-
-
?
2.7.7.B24
additional information
no activity with TTP, UTP and CTP
740285
Vibrio cholerae O1
?
-
-
-
?
2.7.7.B24
additional information
in cytosolic samples from a Vibrio cholerae DncV deletion strain expressing wild-type DncV, only product cyclic Ap(3'-5')G is found, not cyclic Gp(3'-5')G or cyclic Ap(3'-5')A
740285
Vibrio cholerae O1 ATCC 39315
?
-
-
-
?
2.7.7.B24
additional information
no activity with TTP, UTP and CTP
740285
Vibrio cholerae O1 ATCC 39315
?
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
2.7.7.B24
physiological function
disruption of the DncV gene causes a significant defect in intestinal colonization by Vibrio cholerae. Increased expression of DncV severely inhibits Vibrio cholerae chemotaxis, expression of DncV does not change overall motility
Vibrio cholerae O1
General Information (protein specific)
EC Number
General Information
Commentary
Organism
2.7.7.B24
physiological function
disruption of the DncV gene causes a significant defect in intestinal colonization by Vibrio cholerae. Increased expression of DncV severely inhibits Vibrio cholerae chemotaxis, expression of DncV does not change overall motility
Vibrio cholerae O1