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Literature summary extracted from

  • Baumel-Alterzon, S.; Weber, C.; Guillen, N.; Ankri, S.
    Identification of dihydropyrimidine dehydrogenase as a virulence factor essential for the survival of Entamoeba histolytica in glucose-poor environments (2013), Cell. Microbiol., 15, 130-144.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.1 additional information Entamoeba histolytica the enzyme does not use NADPH as cosubstrate ?
-
 ?
1.3.1.1 additional information Entamoeba histolytica HM1:IMSS the enzyme does not use NADPH as cosubstrate ?
-
 ?
1.3.1.1 thymine + NADH + H+ Entamoeba histolytica
-
 5,6-dihydrothymine + NAD+
-
 ?
1.3.1.1 thymine + NADH + H+ Entamoeba histolytica HM1:IMSS
-
 5,6-dihydrothymine + NAD+
-
 ?
1.3.1.1 uracil + NADH + H+ Entamoeba histolytica
-
 5,6-dihydrouracil + NAD+
-
 ?
1.3.1.1 uracil + NADH + H+ Entamoeba histolytica HM1:IMSS
-
 5,6-dihydrouracil + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.1 Entamoeba histolytica
-
-
-
1.3.1.1 Entamoeba histolytica HM1:IMSS
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.1 trophozoite
-
 Entamoeba histolytica
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.1 additional information the enzyme does not use NADPH as cosubstrate Entamoeba histolytica ?
-
 ?
1.3.1.1 additional information the enzyme does not use NADPH as cosubstrate Entamoeba histolytica HM1:IMSS ?
-
 ?
1.3.1.1 thymine + NADH + H+
-
 Entamoeba histolytica 5,6-dihydrothymine + NAD+
-
 ?
1.3.1.1 thymine + NADH + H+
-
 Entamoeba histolytica HM1:IMSS 5,6-dihydrothymine + NAD+
-
 ?
1.3.1.1 uracil + NADH + H+
-
 Entamoeba histolytica 5,6-dihydrouracil + NAD+
-
 ?
1.3.1.1 uracil + NADH + H+
-
 Entamoeba histolytica HM1:IMSS 5,6-dihydrouracil + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.1 DPD
-
 Entamoeba histolytica

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.1 NADH
-
 Entamoeba histolytica

Expression

EC Number Organism Comment Expression
1.3.1.1 Entamoeba histolytica enzyme expression is upregulated 3.8-fold in glucose-starved trophozoites up

General Information

EC Number General Information Comment Organism
1.3.1.1 physiological function the enzyme is essential for the adaption of Entamoeba histolytica to long-term glucose starvation Entamoeba histolytica