Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Liu, W.C.; Wang, Y.Y.; Liu, J.H.; Ke, A.B.; Zheng, Z.H.; Lu, X.H.; Luan, Y.S.; Xiu, Z.L.; Dong, Y.S.
    Wortmannilactones I-L, new NADH-fumarate reductase inhibitors, induced by adding suberoylanilide hydroxamic acid to the culture medium of Talaromyces wortmannii (2016), Bioorg. Med. Chem. Lett., 26, 5328-5333.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.6 pyrvinium pamoate
-
 Ascaris suum
1.3.1.6 wortmannilactone E
-
 Ascaris suum
1.3.1.6 wortmannilactone F
-
 Ascaris suum
1.3.1.6 wortmannilactone H
-
 Ascaris suum
1.3.1.6 wortmannilactone I
-
 Ascaris suum
1.3.1.6 wortmannilactone J
-
 Ascaris suum
1.3.1.6 wortmannilactone K
-
 Ascaris suum
1.3.1.6 wortmannilactone L
-
 Ascaris suum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.6 fumarate + NADH + H+ Ascaris suum
-
 succinate + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.6 Ascaris suum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.6 fumarate + NADH + H+
-
 Ascaris suum succinate + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.6 NADH-fumarate reductase
-
 Ascaris suum
1.3.1.6 NFRD
-
 Ascaris suum

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.6 NADH
-
 Ascaris suum

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.3.1.6 0.0005
-
 pH and temperature not specified in the publication Ascaris suum pyrvinium pamoate
1.3.1.6 0.00084
-
 pH and temperature not specified in the publication Ascaris suum wortmannilactone J
1.3.1.6 0.00084
-
 pH and temperature not specified in the publication Ascaris suum wortmannilactone L
1.3.1.6 0.00085
-
 pH and temperature not specified in the publication Ascaris suum wortmannilactone I
1.3.1.6 0.00135
-
 pH and temperature not specified in the publication Ascaris suum wortmannilactone K