Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Kenmogne, L.C.; Maltais, R.; Poirier, D.
    Synthesis of a dansyl-labeled inhibitor of 17beta-hydroxysteroid dehydrogenase type 3 for optical imaging (2016), Bioorg. Med. Chem. Lett., 26, 2179-2183.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.51 drug development the steroidogenic enzyme 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) is a therapeutic target in the management of androgen-sensitive diseases such as prostate cancer and benign prostate hyperplasia Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.51 (3a,5a)-3-[[(2R,5S)-4-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-2,5-dimethylpiperazin-1-yl]methyl]-17-methylideneandrostan-3-ol
-
 Homo sapiens
1.1.1.51 (3alpha,5alpha)-3-([(2R,5S)-2,5-dimethyl-4-[2-(trifluoromethyl)benzene-1-sulfonyl]piperazin-1-yl]methyl)-3-hydroxyandrostan-17-one i.e. RM-532-105 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.51 testosterone + NADP+ Homo sapiens
-
 androstenedione + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.51 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.51 LNCaP cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.51 testosterone + NADP+
-
 Homo sapiens androstenedione + NADPH + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.51 17beta-HSD3
-
 Homo sapiens
1.1.1.51 17beta-hydroxysteroid dehydrogenase type 3
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.51 NADP+
-
 Homo sapiens
1.1.1.51 NADPH
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.51 0.000085
-
 pH and temperature not specified in the publication Homo sapiens (3alpha,5alpha)-3-([(2R,5S)-2,5-dimethyl-4-[2-(trifluoromethyl)benzene-1-sulfonyl]piperazin-1-yl]methyl)-3-hydroxyandrostan-17-one
1.1.1.51 0.000262
-
 pH and temperature not specified in the publication Homo sapiens (3a,5a)-3-[[(2R,5S)-4-[[5-(dimethylamino)naphthalen-1-yl]sulfonyl]-2,5-dimethylpiperazin-1-yl]methyl]-17-methylideneandrostan-3-ol