EC Number | Cloned (Comment) | Organism |
---|---|---|
1.1.1.149 | expressed in Escherichia coli BL21(DE3) cells | Oryctolagus cuniculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.149 | 3',3'',5',5''-tetrabromophenolphthalein | - |
Oryctolagus cuniculus | |
1.1.1.149 | benzbromarone | - |
Oryctolagus cuniculus | |
1.1.1.149 | Flufenamic acid | - |
Oryctolagus cuniculus | |
1.1.1.149 | galangin | - |
Oryctolagus cuniculus | |
1.1.1.149 | Hexestrol | - |
Oryctolagus cuniculus | |
1.1.1.149 | kaempferol | potent and competitive inhibitor | Oryctolagus cuniculus | |
1.1.1.149 | Mefenamic acid | - |
Oryctolagus cuniculus | |
1.1.1.149 | myricetin | - |
Oryctolagus cuniculus | |
1.1.1.149 | naringenin | - |
Oryctolagus cuniculus | |
1.1.1.149 | Phenolphthalein | - |
Oryctolagus cuniculus | |
1.1.1.149 | quercetin | potent and competitive inhibitor | Oryctolagus cuniculus | |
1.1.1.149 | Sulfobromophthalein | - |
Oryctolagus cuniculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.149 | 0.0005 | - |
5alpha-pregnan-3,20-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0006 | - |
progesterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0006 | - |
isatin | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0008 | - |
5alpha-pregnan-3alpha,20alpha-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0009 | - |
Nonanal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.001 | - |
4-androstene-3,17-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.001 | - |
5beta-pregnan-3,20-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.001 | - |
5beta-Pregnan-3alpha-ol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.001 | - |
4-pregnen-3alpha-ol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.001 | - |
2-tert-butyl-1,4-benzoquinone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0011 | - |
estrone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0012 | - |
4-Nitroacetophenone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0013 | - |
17beta-estradiol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0013 | - |
5alpha-pregnan-3alpha-ol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0014 | - |
5beta-Androstan-3alpha,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0017 | - |
5beta-Androstan-3alpha-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0018 | - |
4-oxo-2-nonenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.002 | - |
6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0022 | - |
20alpha-hydroxyprogesterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0022 | - |
5alpha-androstan-3beta,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0025 | - |
5beta-Androstan-3beta,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0026 | - |
5beta-Pregnan-3alpha,21-diol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0028 | - |
5beta-androstan-3beta-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0029 | - |
7alpha-hydroxy-dehydroepiandrosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0031 | - |
5-androstene-3beta,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0034 | - |
5alpha-dihydrotestosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0041 | - |
5alpha-Androstan-3alpha-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0042 | - |
dehydroepiandrosterone 3-sulfate | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0042 | - |
5alpha-androstan-3alpha,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0053 | - |
4-hydroxy-2-nonenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0055 | - |
trans-2-nonenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0057 | - |
5beta-pregnan-20alpha-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0059 | - |
5alpha-pregnan-20alpha-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0059 | - |
4-oxo-2-hexenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.006 | - |
dehydroepiandrosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.006 | - |
5alpha-Androstan-3beta-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0062 | - |
5beta-androstan-17beta-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0062 | - |
5alpha-Pregnan-3alpha,21-diol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0067 | - |
Estrone 3-sulfate | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0074 | - |
trans-2-hexenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0076 | - |
hexanal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0078 | - |
5beta-pregnan-3alpha,20alpha-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0089 | - |
all-trans-retinal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.011 | - |
5alpha-pregnan-20alpha-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.013 | - |
testosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.014 | - |
acrolein | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.018 | - |
menadione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.018 | - |
5alpha-dihydrotestosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.018 | - |
beta-ionol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.019 | - |
diacetyl | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.034 | - |
befunolol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.053 | - |
alpha-tetralone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.061 | - |
pyridine 3-aldehyde | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.068 | - |
isocaproaldehyde | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.088 | - |
methylglyoxal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.111 | - |
ketotifen | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.112 | - |
(S)-1-tetralol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.131 | - |
(S)-1-indanol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.152 | - |
4-chromanol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.162 | - |
acetoin | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.18 | - |
geraniol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.26 | - |
trans-benzene dihydrodiol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 1.4 | - |
3-deoxyglucosone | at pH 7.4 and 37°C | Oryctolagus cuniculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.1.1.149 | Oryctolagus cuniculus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.1.1.149 | Sepharose 6FF resin column chromatography | Oryctolagus cuniculus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.1.1.149 | ovary | - |
Oryctolagus cuniculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.1.1.149 | (S)-1-indanol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | (S)-1-tetralol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 17beta-estradiol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 2-tert-butyl-1,4-benzoquinone + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 20alpha-hydroxyprogesterone + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 3-deoxyglucosone + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 4-androstene-3,17-dione + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 4-chromanol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 4-hydroxy-2-nonenal + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 4-nitroacetophenone + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 4-oxo-2-hexenal + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 4-oxo-2-nonenal + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 4-pregnen-3alpha-ol-20-one + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5-androstene-3beta,17beta-diol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5alpha-androstan-3alpha,17beta-diol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5alpha-androstan-3alpha-ol-17-one + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5alpha-androstan-3beta,17beta-diol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5alpha-androstan-3beta-ol-17-one + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5alpha-dihydrotestosterone + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5alpha-dihydrotestosterone + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5alpha-pregnan-20alpha-ol-3-one + NADP+ | - |
Oryctolagus cuniculus | 5beta-pregnan-3,20-dione + NADPH + H+ | - |
r | |
1.1.1.149 | 5alpha-pregnan-20alpha-ol-3-one + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5alpha-pregnan-3,20-dione + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5alpha-pregnan-3alpha,20alpha-diol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5alpha-pregnan-3alpha,21-diol-20-one + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5alpha-pregnan-3alpha-ol-20-one + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5beta-androstan-17beta-ol-3-one + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5beta-androstan-3alpha,17beta-diol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5beta-androstan-3alpha-ol-17-one + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5beta-androstan-3beta,17beta-diol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5beta-androstan-3beta-ol-17-one + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5beta-pregnan-20alpha-ol-3-one + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5beta-pregnan-3,20-dione + NADPH + H+ | - |
Oryctolagus cuniculus | 5alpha-pregnan-20alpha-ol-3-one + NADP+ | - |
r | |
1.1.1.149 | 5beta-pregnan-3alpha,20alpha-diol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5beta-pregnan-3alpha,21-diol-20-one + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 5beta-pregnan-3alpha-ol-20-one + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | 7alpha-hydroxy-dehydroepiandrosterone + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | acetoin + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | acrolein + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | all-trans-retinal + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | alpha-tetralone + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | befunolol + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | beta-ionol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | dehydroepiandrosterone + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | dehydroepiandrosterone 3-sulfate + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | diacetyl + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | estrone + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | estrone 3-sulfate + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | geraniol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | hexanal + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | isatin + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | isocaproaldehyde + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | ketotifen + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | menadione + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | methylglyoxal + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | additional information | no activity with 5beta-androstan-17beta-ol-3-one, 5beta-pregnan-20alpha-ol-3-one, testosterone and 20alpha-hydroxy progesterone | Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | nonanal + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | progesterone + NADPH + H+ | - |
Oryctolagus cuniculus | 20alpha-hydroxyprogesterone + NADP+ | - |
? | |
1.1.1.149 | pyridine 3-aldehyde + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | testosterone + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | trans-2-hexenal + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | trans-2-nonenal + NADPH + H+ | - |
Oryctolagus cuniculus | ? | - |
? | |
1.1.1.149 | trans-benzene dihydrodiol + NADP+ | - |
Oryctolagus cuniculus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.1.1.149 | 20alpha-HSD | - |
Oryctolagus cuniculus |
1.1.1.149 | AKR1C5 | - |
Oryctolagus cuniculus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.149 | 0.0085 | - |
all-trans-retinal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.009 | - |
4-hydroxy-2-nonenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.011 | - |
17beta-estradiol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.0115 | - |
4-oxo-2-hexenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.017 | - |
estrone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.017 | - |
5beta-Pregnan-3alpha,21-diol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.018 | - |
5alpha-pregnan-3,20-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.018 | - |
5alpha-Pregnan-3alpha,21-diol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.02 | - |
trans-2-nonenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.02 | - |
ketotifen | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.023 | - |
isocaproaldehyde | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.025 | - |
5alpha-dihydrotestosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.025 | - |
trans-2-hexenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.025 | - |
5alpha-pregnan-3alpha,20alpha-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.027 | - |
progesterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.028 | - |
5beta-pregnan-3,20-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.03 | - |
5beta-Pregnan-3alpha-ol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.032 | - |
Nonanal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.032 | - |
5alpha-androstan-3beta,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.032 | - |
5alpha-pregnan-3alpha-ol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.032 | - |
4-pregnen-3alpha-ol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.033 | - |
geraniol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.033 | - |
5beta-Androstan-3beta,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.035 | - |
acrolein | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.043 | - |
hexanal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.043 | - |
4-androstene-3,17-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.043 | - |
7alpha-hydroxy-dehydroepiandrosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.045 | - |
5beta-androstan-3beta-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.047 | - |
5alpha-dihydrotestosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.048 | - |
20alpha-hydroxyprogesterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.053 | - |
alpha-tetralone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.057 | - |
testosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.067 | - |
5beta-Androstan-3alpha-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.068 | - |
4-chromanol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.077 | - |
5alpha-pregnan-20alpha-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.08 | - |
dehydroepiandrosterone 3-sulfate | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.083 | - |
5alpha-Androstan-3beta-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.085 | - |
5alpha-Androstan-3alpha-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.097 | - |
acetoin | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.098 | - |
Estrone 3-sulfate | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.1 | - |
5-androstene-3beta,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.108 | - |
trans-benzene dihydrodiol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.112 | - |
4-Nitroacetophenone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.112 | - |
4-oxo-2-nonenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.117 | - |
befunolol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.12 | - |
methylglyoxal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.125 | - |
menadione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.132 | - |
pyridine 3-aldehyde | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.137 | - |
isatin | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.153 | - |
5beta-androstan-17beta-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.153 | - |
5beta-pregnan-20alpha-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.155 | - |
dehydroepiandrosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.158 | - |
diacetyl | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.158 | - |
5alpha-pregnan-20alpha-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.167 | - |
6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.183 | - |
3-deoxyglucosone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.183 | - |
2-tert-butyl-1,4-benzoquinone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.2 | - |
(S)-1-indanol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.217 | - |
(S)-1-tetralol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.233 | - |
beta-ionol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.25 | - |
5beta-Androstan-3alpha,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.27 | - |
5alpha-androstan-3alpha,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.283 | - |
5beta-pregnan-3alpha,20alpha-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.1.1.149 | NADH | - |
Oryctolagus cuniculus | |
1.1.1.149 | NADPH | - |
Oryctolagus cuniculus |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.1.1.149 | 0.000022 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | Phenolphthalein | |
1.1.1.149 | 0.000059 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | quercetin | |
1.1.1.149 | 0.00011 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | kaempferol | |
1.1.1.149 | 0.00012 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | benzbromarone | |
1.1.1.149 | 0.00037 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | naringenin | |
1.1.1.149 | 0.00041 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | galangin | |
1.1.1.149 | 0.00064 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | myricetin | |
1.1.1.149 | 0.003 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | 3',3'',5',5''-tetrabromophenolphthalein | |
1.1.1.149 | 0.0064 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | Hexestrol | |
1.1.1.149 | 0.01 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | Mefenamic acid | |
1.1.1.149 | 0.011 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | Sulfobromophthalein | |
1.1.1.149 | 0.026 | - |
at pH 7.4 and 37°C | Oryctolagus cuniculus | Flufenamic acid |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.1.1.149 | 0.018 | - |
geraniol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.062 | - |
4-oxo-2-nonenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.13 | - |
3-deoxyglucosone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.18 | - |
ketotifen | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.35 | - |
isocaproaldehyde | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.42 | - |
trans-benzene dihydrodiol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.45 | - |
4-chromanol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 0.95 | - |
all-trans-retinal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 1 | - |
alpha-tetralone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 1.3 | - |
acetoin | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 1.3 | - |
5alpha-pregnan-20alpha-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 1.4 | - |
methylglyoxal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 1.5 | - |
(S)-1-indanol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 1.6 | - |
4-hydroxy-2-nonenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 1.8 | - |
4-oxo-2-hexenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 2 | - |
menadione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 2 | - |
(S)-1-tetralol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 2.2 | - |
pyridine 3-aldehyde | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 2.5 | - |
acrolein | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 2.7 | - |
5alpha-dihydrotestosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 3 | - |
5alpha-Pregnan-3alpha,21-diol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 3.3 | - |
trans-2-hexenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 3.7 | - |
trans-2-nonenal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 4.3 | - |
testosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 5.7 | - |
hexanal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 6.3 | - |
5beta-Pregnan-3alpha,21-diol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 7.3 | - |
5alpha-dihydrotestosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 8.3 | - |
diacetyl | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 8.7 | - |
17beta-estradiol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 10.1 | - |
beta-ionol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 13.2 | - |
befunolol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 13.3 | - |
5beta-Androstan-3beta,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 13.8 | - |
5alpha-Androstan-3beta-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 14.3 | - |
5alpha-androstan-3beta,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 14.3 | - |
5alpha-pregnan-20alpha-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 14.7 | - |
Estrone 3-sulfate | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 15 | - |
7alpha-hydroxy-dehydroepiandrosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 15.1 | - |
estrone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 16 | - |
5beta-androstan-3beta-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 18.3 | - |
dehydroepiandrosterone 3-sulfate | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 20 | - |
5alpha-Androstan-3alpha-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 21.7 | - |
20alpha-hydroxyprogesterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 25 | - |
5beta-androstan-17beta-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 25 | - |
5alpha-pregnan-3alpha-ol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 26.7 | - |
dehydroepiandrosterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 26.7 | - |
5beta-pregnan-20alpha-ol-3-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 28.3 | - |
5beta-pregnan-3,20-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 30 | - |
5beta-Pregnan-3alpha-ol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 30 | - |
5alpha-pregnan-3alpha,20alpha-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 31.7 | - |
5-androstene-3beta,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 31.7 | - |
4-pregnen-3alpha-ol-20-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 35 | - |
Nonanal | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 36.7 | - |
5alpha-pregnan-3,20-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 36.7 | - |
5beta-pregnan-3alpha,20alpha-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 40 | - |
5beta-Androstan-3alpha-ol-17-one | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 43.3 | - |
4-androstene-3,17-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 45 | - |
progesterone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 63.3 | - |
5alpha-androstan-3alpha,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 83.3 | - |
6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 93.3 | - |
4-Nitroacetophenone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 183.3 | - |
5beta-Androstan-3alpha,17beta-diol | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 183.3 | - |
2-tert-butyl-1,4-benzoquinone | at pH 7.4 and 37°C | Oryctolagus cuniculus | |
1.1.1.149 | 233.3 | - |
isatin | at pH 7.4 and 37°C | Oryctolagus cuniculus |