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Literature summary extracted from

  • Endo, S.; Arai, Y.; Hara, A.; Kitade, Y.; Bunai, Y.; El-Kabbani, O.; Matsunaga, T.
    Substrate specificity and inhibitor sensitivity of rabbit 20alpha-hydroxysteroid dehydrogenase (2013), Biol. Pharm. Bull., 36, 1514-1518.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.149 expressed in Escherichia coli BL21(DE3) cells Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.149 3',3'',5',5''-tetrabromophenolphthalein
-
Oryctolagus cuniculus
1.1.1.149 benzbromarone
-
Oryctolagus cuniculus
1.1.1.149 Flufenamic acid
-
Oryctolagus cuniculus
1.1.1.149 galangin
-
Oryctolagus cuniculus
1.1.1.149 Hexestrol
-
Oryctolagus cuniculus
1.1.1.149 kaempferol potent and competitive inhibitor Oryctolagus cuniculus
1.1.1.149 Mefenamic acid
-
Oryctolagus cuniculus
1.1.1.149 myricetin
-
Oryctolagus cuniculus
1.1.1.149 naringenin
-
Oryctolagus cuniculus
1.1.1.149 Phenolphthalein
-
Oryctolagus cuniculus
1.1.1.149 quercetin potent and competitive inhibitor Oryctolagus cuniculus
1.1.1.149 Sulfobromophthalein
-
Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.149 0.0005
-
5alpha-pregnan-3,20-dione at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0006
-
progesterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0006
-
isatin at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0008
-
5alpha-pregnan-3alpha,20alpha-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0009
-
Nonanal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.001
-
4-androstene-3,17-dione at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.001
-
5beta-pregnan-3,20-dione at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.001
-
5beta-Pregnan-3alpha-ol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.001
-
4-pregnen-3alpha-ol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.001
-
2-tert-butyl-1,4-benzoquinone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0011
-
estrone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0012
-
4-Nitroacetophenone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0013
-
17beta-estradiol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0013
-
5alpha-pregnan-3alpha-ol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0014
-
5beta-Androstan-3alpha,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0017
-
5beta-Androstan-3alpha-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0018
-
4-oxo-2-nonenal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.002
-
6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0022
-
20alpha-hydroxyprogesterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0022
-
5alpha-androstan-3beta,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0025
-
5beta-Androstan-3beta,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0026
-
5beta-Pregnan-3alpha,21-diol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0028
-
5beta-androstan-3beta-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0029
-
7alpha-hydroxy-dehydroepiandrosterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0031
-
5-androstene-3beta,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0034
-
5alpha-dihydrotestosterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0041
-
5alpha-Androstan-3alpha-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0042
-
dehydroepiandrosterone 3-sulfate at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0042
-
5alpha-androstan-3alpha,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0053
-
4-hydroxy-2-nonenal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0055
-
trans-2-nonenal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0057
-
5beta-pregnan-20alpha-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0059
-
5alpha-pregnan-20alpha-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0059
-
4-oxo-2-hexenal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.006
-
dehydroepiandrosterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.006
-
5alpha-Androstan-3beta-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0062
-
5beta-androstan-17beta-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0062
-
5alpha-Pregnan-3alpha,21-diol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0067
-
Estrone 3-sulfate at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0074
-
trans-2-hexenal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0076
-
hexanal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0078
-
5beta-pregnan-3alpha,20alpha-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0089
-
all-trans-retinal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.011
-
5alpha-pregnan-20alpha-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.013
-
testosterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.014
-
acrolein at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.018
-
menadione at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.018
-
5alpha-dihydrotestosterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.018
-
beta-ionol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.019
-
diacetyl at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.034
-
befunolol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.053
-
alpha-tetralone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.061
-
pyridine 3-aldehyde at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.068
-
isocaproaldehyde at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.088
-
methylglyoxal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.111
-
ketotifen at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.112
-
(S)-1-tetralol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.131
-
(S)-1-indanol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.152
-
4-chromanol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.162
-
acetoin at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.18
-
geraniol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.26
-
trans-benzene dihydrodiol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 1.4
-
3-deoxyglucosone at pH 7.4 and 37°C Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.149 Oryctolagus cuniculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.149 Sepharose 6FF resin column chromatography Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.149 ovary
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.149 (S)-1-indanol + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 (S)-1-tetralol + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 17beta-estradiol + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 2-tert-butyl-1,4-benzoquinone + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 20alpha-hydroxyprogesterone + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 3-deoxyglucosone + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 4-androstene-3,17-dione + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 4-chromanol + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 4-hydroxy-2-nonenal + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 4-nitroacetophenone + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 4-oxo-2-hexenal + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 4-oxo-2-nonenal + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 4-pregnen-3alpha-ol-20-one + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5-androstene-3beta,17beta-diol + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5alpha-androstan-3alpha,17beta-diol + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5alpha-androstan-3alpha-ol-17-one + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5alpha-androstan-3beta,17beta-diol + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5alpha-androstan-3beta-ol-17-one + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5alpha-dihydrotestosterone + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5alpha-dihydrotestosterone + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5alpha-pregnan-20alpha-ol-3-one + NADP+
-
Oryctolagus cuniculus 5beta-pregnan-3,20-dione + NADPH + H+
-
r
1.1.1.149 5alpha-pregnan-20alpha-ol-3-one + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5alpha-pregnan-3,20-dione + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5alpha-pregnan-3alpha,20alpha-diol + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5alpha-pregnan-3alpha,21-diol-20-one + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5alpha-pregnan-3alpha-ol-20-one + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5beta-androstan-17beta-ol-3-one + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5beta-androstan-3alpha,17beta-diol + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5beta-androstan-3alpha-ol-17-one + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5beta-androstan-3beta,17beta-diol + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5beta-androstan-3beta-ol-17-one + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5beta-pregnan-20alpha-ol-3-one + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5beta-pregnan-3,20-dione + NADPH + H+
-
Oryctolagus cuniculus 5alpha-pregnan-20alpha-ol-3-one + NADP+
-
r
1.1.1.149 5beta-pregnan-3alpha,20alpha-diol + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5beta-pregnan-3alpha,21-diol-20-one + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 5beta-pregnan-3alpha-ol-20-one + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 7alpha-hydroxy-dehydroepiandrosterone + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 acetoin + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 acrolein + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 all-trans-retinal + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 alpha-tetralone + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 befunolol + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 beta-ionol + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 dehydroepiandrosterone + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 dehydroepiandrosterone 3-sulfate + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 diacetyl + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 estrone + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 estrone 3-sulfate + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 geraniol + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 hexanal + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 isatin + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 isocaproaldehyde + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 ketotifen + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 menadione + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 methylglyoxal + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 additional information no activity with 5beta-androstan-17beta-ol-3-one, 5beta-pregnan-20alpha-ol-3-one, testosterone and 20alpha-hydroxy progesterone Oryctolagus cuniculus ?
-
?
1.1.1.149 nonanal + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 progesterone + NADPH + H+
-
Oryctolagus cuniculus 20alpha-hydroxyprogesterone + NADP+
-
?
1.1.1.149 pyridine 3-aldehyde + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 testosterone + NADP+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 trans-2-hexenal + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 trans-2-nonenal + NADPH + H+
-
Oryctolagus cuniculus ?
-
?
1.1.1.149 trans-benzene dihydrodiol + NADP+
-
Oryctolagus cuniculus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.149 20alpha-HSD
-
Oryctolagus cuniculus
1.1.1.149 AKR1C5
-
Oryctolagus cuniculus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.149 0.0085
-
all-trans-retinal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.009
-
4-hydroxy-2-nonenal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.011
-
17beta-estradiol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.0115
-
4-oxo-2-hexenal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.017
-
estrone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.017
-
5beta-Pregnan-3alpha,21-diol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.018
-
5alpha-pregnan-3,20-dione at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.018
-
5alpha-Pregnan-3alpha,21-diol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.02
-
trans-2-nonenal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.02
-
ketotifen at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.023
-
isocaproaldehyde at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.025
-
5alpha-dihydrotestosterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.025
-
trans-2-hexenal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.025
-
5alpha-pregnan-3alpha,20alpha-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.027
-
progesterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.028
-
5beta-pregnan-3,20-dione at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.03
-
5beta-Pregnan-3alpha-ol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.032
-
Nonanal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.032
-
5alpha-androstan-3beta,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.032
-
5alpha-pregnan-3alpha-ol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.032
-
4-pregnen-3alpha-ol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.033
-
geraniol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.033
-
5beta-Androstan-3beta,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.035
-
acrolein at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.043
-
hexanal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.043
-
4-androstene-3,17-dione at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.043
-
7alpha-hydroxy-dehydroepiandrosterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.045
-
5beta-androstan-3beta-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.047
-
5alpha-dihydrotestosterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.048
-
20alpha-hydroxyprogesterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.053
-
alpha-tetralone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.057
-
testosterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.067
-
5beta-Androstan-3alpha-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.068
-
4-chromanol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.077
-
5alpha-pregnan-20alpha-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.08
-
dehydroepiandrosterone 3-sulfate at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.083
-
5alpha-Androstan-3beta-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.085
-
5alpha-Androstan-3alpha-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.097
-
acetoin at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.098
-
Estrone 3-sulfate at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.1
-
5-androstene-3beta,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.108
-
trans-benzene dihydrodiol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.112
-
4-Nitroacetophenone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.112
-
4-oxo-2-nonenal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.117
-
befunolol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.12
-
methylglyoxal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.125
-
menadione at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.132
-
pyridine 3-aldehyde at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.137
-
isatin at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.153
-
5beta-androstan-17beta-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.153
-
5beta-pregnan-20alpha-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.155
-
dehydroepiandrosterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.158
-
diacetyl at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.158
-
5alpha-pregnan-20alpha-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.167
-
6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.183
-
3-deoxyglucosone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.183
-
2-tert-butyl-1,4-benzoquinone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.2
-
(S)-1-indanol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.217
-
(S)-1-tetralol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.233
-
beta-ionol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.25
-
5beta-Androstan-3alpha,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.27
-
5alpha-androstan-3alpha,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.283
-
5beta-pregnan-3alpha,20alpha-diol at pH 7.4 and 37°C Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.149 NADH
-
Oryctolagus cuniculus
1.1.1.149 NADPH
-
Oryctolagus cuniculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.149 0.000022
-
at pH 7.4 and 37°C Oryctolagus cuniculus Phenolphthalein
1.1.1.149 0.000059
-
at pH 7.4 and 37°C Oryctolagus cuniculus quercetin
1.1.1.149 0.00011
-
at pH 7.4 and 37°C Oryctolagus cuniculus kaempferol
1.1.1.149 0.00012
-
at pH 7.4 and 37°C Oryctolagus cuniculus benzbromarone
1.1.1.149 0.00037
-
at pH 7.4 and 37°C Oryctolagus cuniculus naringenin
1.1.1.149 0.00041
-
at pH 7.4 and 37°C Oryctolagus cuniculus galangin
1.1.1.149 0.00064
-
at pH 7.4 and 37°C Oryctolagus cuniculus myricetin
1.1.1.149 0.003
-
at pH 7.4 and 37°C Oryctolagus cuniculus 3',3'',5',5''-tetrabromophenolphthalein
1.1.1.149 0.0064
-
at pH 7.4 and 37°C Oryctolagus cuniculus Hexestrol
1.1.1.149 0.01
-
at pH 7.4 and 37°C Oryctolagus cuniculus Mefenamic acid
1.1.1.149 0.011
-
at pH 7.4 and 37°C Oryctolagus cuniculus Sulfobromophthalein
1.1.1.149 0.026
-
at pH 7.4 and 37°C Oryctolagus cuniculus Flufenamic acid

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.1.1.149 0.018
-
geraniol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.062
-
4-oxo-2-nonenal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.13
-
3-deoxyglucosone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.18
-
ketotifen at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.35
-
isocaproaldehyde at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.42
-
trans-benzene dihydrodiol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.45
-
4-chromanol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 0.95
-
all-trans-retinal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 1
-
alpha-tetralone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 1.3
-
acetoin at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 1.3
-
5alpha-pregnan-20alpha-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 1.4
-
methylglyoxal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 1.5
-
(S)-1-indanol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 1.6
-
4-hydroxy-2-nonenal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 1.8
-
4-oxo-2-hexenal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 2
-
menadione at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 2
-
(S)-1-tetralol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 2.2
-
pyridine 3-aldehyde at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 2.5
-
acrolein at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 2.7
-
5alpha-dihydrotestosterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 3
-
5alpha-Pregnan-3alpha,21-diol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 3.3
-
trans-2-hexenal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 3.7
-
trans-2-nonenal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 4.3
-
testosterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 5.7
-
hexanal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 6.3
-
5beta-Pregnan-3alpha,21-diol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 7.3
-
5alpha-dihydrotestosterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 8.3
-
diacetyl at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 8.7
-
17beta-estradiol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 10.1
-
beta-ionol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 13.2
-
befunolol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 13.3
-
5beta-Androstan-3beta,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 13.8
-
5alpha-Androstan-3beta-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 14.3
-
5alpha-androstan-3beta,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 14.3
-
5alpha-pregnan-20alpha-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 14.7
-
Estrone 3-sulfate at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 15
-
7alpha-hydroxy-dehydroepiandrosterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 15.1
-
estrone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 16
-
5beta-androstan-3beta-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 18.3
-
dehydroepiandrosterone 3-sulfate at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 20
-
5alpha-Androstan-3alpha-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 21.7
-
20alpha-hydroxyprogesterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 25
-
5beta-androstan-17beta-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 25
-
5alpha-pregnan-3alpha-ol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 26.7
-
dehydroepiandrosterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 26.7
-
5beta-pregnan-20alpha-ol-3-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 28.3
-
5beta-pregnan-3,20-dione at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 30
-
5beta-Pregnan-3alpha-ol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 30
-
5alpha-pregnan-3alpha,20alpha-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 31.7
-
5-androstene-3beta,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 31.7
-
4-pregnen-3alpha-ol-20-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 35
-
Nonanal at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 36.7
-
5alpha-pregnan-3,20-dione at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 36.7
-
5beta-pregnan-3alpha,20alpha-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 40
-
5beta-Androstan-3alpha-ol-17-one at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 43.3
-
4-androstene-3,17-dione at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 45
-
progesterone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 63.3
-
5alpha-androstan-3alpha,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 83.3
-
6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 93.3
-
4-Nitroacetophenone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 183.3
-
5beta-Androstan-3alpha,17beta-diol at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 183.3
-
2-tert-butyl-1,4-benzoquinone at pH 7.4 and 37°C Oryctolagus cuniculus
1.1.1.149 233.3
-
isatin at pH 7.4 and 37°C Oryctolagus cuniculus