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Literature summary extracted from

  • Prabhu, A.V.; Sharpe, L.J.; Brown, A.J.
    The sterol-based transcriptional control of human 7-dehydrocholesterol reductase (DHCR7): Evidence of a cooperative regulatory program in cholesterol synthesis (2014), Biochim. Biophys. Acta, 1842, 1431-1439.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.1.21 sterol regulatory element two sterol regulatory elements that bind sterol regulatory element-binding protein-2 work in cooperation to synergistically activate the enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.21 cholesta-5,7-dien-3beta-ol + NADPH + H+ Homo sapiens
-
 cholesterol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.21 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.21 cholesta-5,7-dien-3beta-ol + NADPH + H+
-
 Homo sapiens cholesterol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.21 Dhcr7
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.21 NADPH
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.3.1.21 malfunction enzyme absence leads to the devastating fetal developmental disorder Smith-Lemli-Opitz syndrome Homo sapiens
1.3.1.21 metabolism the enzyme catalyzes the final step of cholesterol synthesis via the Kandutsch-Russell pathway, and is crucial in maintaining cellular cholesterol levels Homo sapiens