Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Franklin, E.; Mantle, T.; Dunne, A.
    Activation of human biliverdin-IXalpha reductase by urea: generation of kinetically distinct forms during the unfolding pathway (2013), Biochim. Biophys. Acta, 1834, 2573-2578.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.3.1.24 Urea the enzyme is activated at low concentrations of urea Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.24 Biliverdin
-
 Homo sapiens
1.3.1.24 NAD+
-
 Homo sapiens
1.3.1.24 NADP+
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.24 0.001
-
 NADPH in the absence of urea, at pH 7.2 and 25°C Homo sapiens
1.3.1.24 0.003
-
 NADPH in the presence of 3 M urea, at pH 7.2 and 25°C Homo sapiens
1.3.1.24 0.33
-
 NADH in the absence of urea, at pH 7.2 and 25°C Homo sapiens
1.3.1.24 2
-
 NADH in the presence of 3 M urea, at pH 7.2 and 25°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.24 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.24 biliverdin + NADH + H+ Homo sapiens
-
 bilirubin + NAD+
-
 r
1.3.1.24 biliverdin + NADPH + H+ Homo sapiens
-
 bilirubin + NADP+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.24 Homo sapiens P53004
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.24 biliverdin + NADH + H+
-
 Homo sapiens bilirubin + NAD+
-
 r
1.3.1.24 biliverdin + NADPH + H+
-
 Homo sapiens bilirubin + NADP+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.3.1.24 biliverdin-IXalpha reductase
-
 Homo sapiens
1.3.1.24 BVR-A
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.24 NADH
-
 Homo sapiens
1.3.1.24 NADPH
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.1.24 0.00035
-
 NADP+ in the presence of 3 M urea, at pH 7.2 and 25°C Homo sapiens
1.3.1.24 0.0016
-
 NADP+ in the absence of urea, at pH 7.2 and 25°C Homo sapiens
1.3.1.24 0.028
-
 Biliverdin in the absence of urea, at pH 7.2 and 25°C Homo sapiens
1.3.1.24 0.147
-
 Biliverdin in the presence of 3 M urea, at pH 7.2 and 25°C Homo sapiens
1.3.1.24 0.3
-
 NAD+ in the absence of urea, at pH 7.2 and 25°C Homo sapiens
1.3.1.24 1.7
-
 NAD+ in the presence of 3 M urea, at pH 7.2 and 25°C Homo sapiens