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Literature summary extracted from

  • Luo, M.; Tanner, J.J.
    Structural basis of substrate recognition by aldehyde dehydrogenase 7A1 (2015), Biochemistry, 54, 5513-5522.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.2.1.3 apoenzyme and in complex with L-2-aminoadipate or NAD+, sitting drop vapor diffusion method, using 0.1 M MgCl2, 0.1 M sodium acetate trihydrate, 0.1 M Tris-HCl (pH 8.0) and 20% (w/v) PEG 4000, or 0.1 M HEPES (pH 7.5), 0.1 M MgCl2 and 20% (w/v) PEG 3350, or 0.2 M ammonium sulfate, 20% (w/v) polyethylene glycol (PEG) 3350 and 0.1 mM Bis-Tris (pH 6.5) Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.3 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.3 alpha-aminoadipate semialdehyde + NAD+ + H2O Homo sapiens
-
 alpha-aminoadipate + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Homo sapiens P49419
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 alpha-aminoadipate semialdehyde + NAD+ + H2O
-
 Homo sapiens alpha-aminoadipate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.3 aldehyde dehydrogenase 7A1
-
 Homo sapiens
1.2.1.3 Aldh7a1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Homo sapiens