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Literature summary extracted from

  • Pemberton, T.A.; Srivastava, D.; Sanyal, N.; Henzl, M.T.; Becker, D.F.; Tanner, J.J.
    Structural studies of yeast delta(1)-pyrroline-5-carboxylate dehydrogenase (ALDH4A1): active site flexibility and oligomeric state (2014), Biochemistry, 53, 1350-1359.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.88 expression in Escherichia coli Homo sapiens
1.2.1.88 expression in Escherichia coli Saccharomyces cerevisiae

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.2.1.88 apoenzyme and in complex with NAD+, to 1.95 and 2.17 A resolution, respectively Saccharomyces cerevisiae
1.2.1.88 the substrate-free form displays multiple active site conformations. Protein forms a trimer-of-dimers hexamer in solution Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.2.1.88 W193A mutation disrupts hexamer formation, mutant forms a dimer Saccharomyces cerevisiae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.88 0.104
-
1-pyrroline-5-carboxylate pH 7.5, 20°C Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.88 Homo sapiens P30038
-
-
1.2.1.88 Saccharomyces cerevisiae P07275
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.88 1-pyrroline-5-carboxylate + NADH + H+
-
Saccharomyces cerevisiae L-proline + NAD+
-
?

Subunits

EC Number Subunits Comment Organism
1.2.1.88 hexamer crystallization data Saccharomyces cerevisiae

Synonyms

EC Number Synonyms Comment Organism
1.2.1.88 Aldh4a1
-
Homo sapiens
1.2.1.88 Aldh4a1
-
Saccharomyces cerevisiae
1.2.1.88 Put2
-
Saccharomyces cerevisiae

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.2.1.88 1.5
-
1-pyrroline-5-carboxylate pH 7.5, 20°C Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.88 NADH
-
Saccharomyces cerevisiae

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.2.1.88 14
-
1-pyrroline-5-carboxylate pH 7.5, 20°C Saccharomyces cerevisiae