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Literature summary extracted from
- The flexible loop of Staphylococcus aureus IsdG is required for its degradation in the absence of heme (2011), Biochemistry, 50, 6730-6737.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.99.48 | cytoplasm | - |
Staphylococcus aureus | 5737 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.99.48 | Staphylococcus aureus | A6QG37 | - |
- |
| 1.14.99.48 | Staphylococcus aureus Newman | A6QG37 | - |
- |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.99.48 | isdG | - |
Staphylococcus aureus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.14.99.48 | metabolism | in the absence of heme, isoform IsdG is targeted for degradation by internally coded sequences. A flexible loop near the heme-binding pocket is required for IsdG degradation in the absence of heme. IsdG stability is increased by inhibiting ATPases | Staphylococcus aureus |
| 1.14.99.48 | physiological function | in the vertebrate host, Staphylococcus aureus fulfills its iron requirement by obtaining heme-iron from host hemoproteins via IsdG- and IsdI-mediated heme degradation. Isoforms IsdG and IsdI are structurally and mechanistically analogous but are differentially regulated by iron and heme availability | Staphylococcus aureus |
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