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Literature summary extracted from

  • Mitic, T.; Shave, S.; Semjonous, N.; McNae, I.; Cobice, D.F.; Lavery, G.G.; Webster, S.P.; Hadoke, P.W.; Walker, B.R.; Andrew, R.
    11beta-Hydroxysteroid dehydrogenase type 1 contributes to the balance between 7-keto- and 7-hydroxy-oxysterols in vivo (2013), Biochem. Pharmacol., 86, 146-153.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.146 expressed in HEK-293 cells Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.146 7-oxo-cholesterol
-
 Mus musculus
1.1.1.146 7beta-hydroxycholesterol
-
 Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.146 0.0002
-
 11-Dehydrocorticosterone recombinant enzyme, at pH 7.4 and 37°C Mus musculus
1.1.1.146 0.0013
-
 11-Dehydrocorticosterone native enzyme, at pH 7.4 and 37°C Mus musculus
1.1.1.146 0.00178
-
 corticosterone recombinant enzyme, at pH 7.4 and 37°C Mus musculus
1.1.1.146 0.0042
-
 corticosterone native enzyme, at pH 7.4 and 37°C Mus musculus
1.1.1.146 0.3176
-
 7beta-hydroxycholesterol recombinant enzyme, at pH 7.4 and 37°C Mus musculus
1.1.1.146 1.269
-
 7-oxo-cholesterol recombinant enzyme, at pH 7.4 and 37°C Mus musculus
1.1.1.146 3.5
-
 7beta-hydroxycholesterol native enzyme, at pH 7.4 and 37°C Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.146 microsome
-
 Mus musculus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 hepatocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 11-dehydrocorticosterone + NADPH + H+
-
 Mus musculus corticosterone + NADP+
-
 r
1.1.1.146 7-oxo-cholesterol + NADP+
-
 Mus musculus 7beta-hydroxycholesterol + NADPH + H+
-
 r
1.1.1.146 7beta-hydroxycholesterol + NADPH + H+
-
 Mus musculus 7-oxo-cholesterol + NADP+
-
 r
1.1.1.146 corticosterone + NADP+
-
 Mus musculus 11-dehydrocorticosterone + NADPH + H+
-
 r

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-hydroxysteroid dehydrogenase type 1
-
 Mus musculus
1.1.1.146 11betaHSD1
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.146 NADP+
-
 Mus musculus
1.1.1.146 NADPH
-
 Mus musculus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.146 0.0022
-
 recombinant enzyme, at pH 7.4 and 37°C Mus musculus 7beta-hydroxycholesterol
1.1.1.146 0.0194
-
 recombinant enzyme, at pH 7.4 and 37°C Mus musculus 7-oxo-cholesterol