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Literature summary extracted from

  • Richarme, G.; Marguet, E.; Forterre, P.; Ishino, S.; Ishino, Y.
    DJ-1 family Maillard deglycases prevent acrylamide formation (2016), Biochem. Biophys. Res. Commun., 478, 1111-1116.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.2.1.130 bovine serum albumin activates the glyoxalase activity Pyrococcus furiosus

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.124 Escherichia coli P45470
-
-
3.5.1.124 Homo sapiens Q99497
-
-
3.5.1.124 Pyrococcus furiosus Q51732
-
-
4.2.1.130 Pyrococcus furiosus Q51732
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.124 an S-(1-hydroxy-2-oxopropyl)-[protein]-L-arginine + H2O
-
 Pyrococcus furiosus a [protein]-L-arginine + (R)-lactate
-
 ?
3.5.1.124 an S-(1-hydroxy-2-oxopropyl)-[protein]-L-arginine + H2O
-
 Homo sapiens a [protein]-L-arginine + (R)-lactate
-
 ?
3.5.1.124 an S-(1-hydroxy-2-oxopropyl)-[protein]-L-arginine + H2O
-
 Escherichia coli a [protein]-L-arginine + (R)-lactate
-
 ?
3.5.1.124 an S-(1-hydroxy-2-oxopropyl)-[protein]-L-cysteine + H2O
-
 Pyrococcus furiosus a [protein]-L-cysteine + (R)-lactate
-
 ?
3.5.1.124 an S-(1-hydroxy-2-oxopropyl)-[protein]-L-cysteine + H2O
-
 Homo sapiens a [protein]-L-cysteine + (R)-lactate
-
 ?
3.5.1.124 an S-(1-hydroxy-2-oxopropyl)-[protein]-L-cysteine + H2O
-
 Escherichia coli a [protein]-L-cysteine + (R)-lactate
-
 ?
3.5.1.124 an S-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H2O
-
 Pyrococcus furiosus a [protein]-L-lysine + (R)-lactate
-
 ?
3.5.1.124 an S-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H2O
-
 Homo sapiens a [protein]-L-lysine + (R)-lactate
-
 ?
3.5.1.124 an S-(1-hydroxy-2-oxopropyl)-[protein]-L-lysine + H2O
-
 Escherichia coli a [protein]-L-lysine + (R)-lactate
-
 ?
4.2.1.130 2-oxopropanal + H2O i.e. methylglyoxal Pyrococcus furiosus (R)-lactate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.124 deglycase
-
 Pyrococcus furiosus
3.5.1.124 deglycase
-
 Homo sapiens
3.5.1.124 deglycase
-
 Escherichia coli
3.5.1.124 DJ-1
-
 Homo sapiens
3.5.1.124 Maillard deglycase
-
 Pyrococcus furiosus
3.5.1.124 Maillard deglycase
-
 Homo sapiens
3.5.1.124 Maillard deglycase
-
 Escherichia coli
3.5.1.124 PARK7
-
 Homo sapiens
3.5.1.124 PfpI
-
 Pyrococcus furiosus
3.5.1.124 yhbO
-
 Escherichia coli
4.2.1.130 glyoxalase III
-
 Pyrococcus furiosus
4.2.1.130 PfpI
-
 Pyrococcus furiosus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.1.124 55
-
 assay at Homo sapiens
3.5.1.124 70
-
 assay at Escherichia coli
3.5.1.124 70
-
 assay at, deglycase activity Pyrococcus furiosus
4.2.1.130 85
-
 assay at Pyrococcus furiosus

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
3.5.1.124 55 95 enzyme activity is reduced by 72% for YhbO 70°C, YhbO is inactive at 95°C Escherichia coli
3.5.1.124 55 95 enzyme activity is reduced by 74% for DJ-1 at 70°C, DJ-1 is inactive at 95°C Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.124 7
-
 assay at Pyrococcus furiosus
3.5.1.124 7
-
 assay at Homo sapiens
3.5.1.124 7
-
 assay at Escherichia coli
4.2.1.130 7
-
 assay at Pyrococcus furiosus

General Information

EC Number General Information Comment Organism
3.5.1.124 evolution the enzyme PfpI belongs to the PfpI/Hsp31/DJ-1 superfamily Pyrococcus furiosus
3.5.1.124 physiological function the enzyme prevents acrylamide formation in vivo, acrylamide formation in the glyoxal/asparagine mixture is reduced by 72% by PfpI Pyrococcus furiosus
3.5.1.124 physiological function the enzyme prevents acrylamide formation in vivo, acrylamide formation in the glyoxal/asparagine mixture is reduced by 78% by YhbO Escherichia coli
3.5.1.124 physiological function the enzyme prevents acrylamide formation in vivo, acrylamide formation in the glyoxal/asparagine mixture is reduced by 98% by DJ-1 Homo sapiens
4.2.1.130 evolution the enzyme PfpI belongs to the PfpI/Hsp31/DJ-1 superfamily Pyrococcus furiosus
4.2.1.130 physiological function the enzyme prevents acrylamide formation in vivo, acrylamide formation in the glyoxal/asparagine mixture is reduced by 72% by PfpI Pyrococcus furiosus