EC Number | Cloned (Comment) | Organism |
---|---|---|
1.2.1.79 | - |
Streptococcus pyogenes |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.2.1.79 | structures in a binary complex with succinic semialdehyde as the substrate and a ternary complex with the substrate succinic semialdehyde and the inhibitory succinate semialdehyde, at 2.4 A resolution for both structures | Streptococcus pyogenes |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.79 | succinate semialdehyde | uncompetitive substrate inhibition above 0.02 mM, in the presence of NADP+. Substrate inhibition is induced by the binding of inhibitory succinate semialdehyde in the cofactor-binding site, instead of NADP+ | Streptococcus pyogenes |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.79 | 3.95 | - |
succinate semialdehyde | pH 7.0, 30°C | Streptococcus pyogenes |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.79 | Streptococcus pyogenes | A0A0J9X1M8 | - |
- |
1.2.1.79 | Streptococcus pyogenes MGAS1882 | A0A0J9X1M8 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.79 | succinate semialdehyde + NADP+ + H2O | - |
Streptococcus pyogenes | succinate + NADPH + 2 H+ | - |
? | |
1.2.1.79 | succinate semialdehyde + NADP+ + H2O | - |
Streptococcus pyogenes MGAS1882 | succinate + NADPH + 2 H+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.2.1.79 | gabD | - |
Streptococcus pyogenes |
1.2.1.79 | succinic semialdehyde dehydrogenase | - |
Streptococcus pyogenes |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.79 | 1.69 | - |
succinate semialdehyde | pH 7.0, 30°C | Streptococcus pyogenes |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.79 | NADP+ | - |
Streptococcus pyogenes |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.79 | 0.1 | - |
succinate semialdehyde | pH 7.0, 30°C | Streptococcus pyogenes |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.79 | 0.43 | - |
succinate semialdehyde | pH 7.0, 30°C | Streptococcus pyogenes |