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Literature summary extracted from

  • Itoi, S.; Terao, M.; Murota, H.; Katayama, I.
    11beta-Hydroxysteroid dehydrogenase 1 contributes to the pro-inflammatory response of keratinocytes (2013), Biochem. Biophys. Res. Commun., 440, 265-270.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.146 32000
-
 x * 32000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.146 cortisone + NADPH + H+ Homo sapiens
-
 cortisol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.146 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.146 keratinocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.146 cortisone + NADPH + H+
-
 Homo sapiens cortisol + NADP+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.146 ? x * 32000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.1.1.146 11beta-HSD1
-
 Homo sapiens
1.1.1.146 11beta-hydroxysteroid dehydrogenase 1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.146 NADPH
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.1.1.146 Homo sapiens expression of isoform 11beta-HSD1 is induced by UV-B irradiation and in response to the pro-inflammatory cytokines, interleukin-1beta and tumor necrosis factor alpha up

General Information

EC Number General Information Comment Organism
1.1.1.146 physiological function isoform 11beta-HSD1 modulates a pro-inflammatory response in normal human epidermal keratinocytes by altering cortisol production Homo sapiens