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Literature summary extracted from

  • Pemberton, T.A.; Tanner, J.J.
    Structural basis of substrate selectivity of delta(1)-pyrroline-5-carboxylate dehydrogenase (ALDH4A1): semialdehyde chain length (2013), Arch. Biochem. Biophys., 538, 34-40.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.88
-
 Mus musculus

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.2.1.88 complexed with glutarate, succinate, malonate, glyoxylate, and acetate Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.88 glyoxylate
-
 Mus musculus
1.2.1.88 L-glutamate
-
 Mus musculus
1.2.1.88 L-glutarate
-
 Mus musculus
1.2.1.88 additional information not inhibitory: malonate Mus musculus
1.2.1.88 succinate
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.88 Mus musculus Q8CHT0
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.88 succinate semialdehyde + NAD+ + H2O
-
 Mus musculus succinate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.88 Aldh4a1
-
 Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.1.88 0.27
-
 glyoxylate pH 7.0, 20°C Mus musculus
1.2.1.88 12
-
 L-glutamate pH 7.0, 20°C Mus musculus
1.2.1.88 30
-
 L-glutarate pH 7.0, 20°C Mus musculus
1.2.1.88 58
-
 succinate pH 7.0, 20°C Mus musculus