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Literature summary extracted from

  • Riccardi, G.; Pasca, M.R.; Chiarelli, L.R.; Manina, G.; Mattevi, A.; Binda, C.
    The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis (2013), Appl. Microbiol. Biotechnol., 97, 8841-8848.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.98.3 1-[(4-tert-butylphenyl)methyl]-3-nitro-1H-1,2,4-triazole
-
 Mycobacterium tuberculosis
1.1.98.3 2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one
-
 Mycobacterium tuberculosis
1.1.98.3 3-nitro-N-[(1R)-1-phenylethyl]-5-(trifluoromethyl)benzamide
-
 Mycobacterium tuberculosis
1.1.98.3 6-bromo-3-methyl-8-nitro-2-phenylquinoline
-
 Mycobacterium tuberculosis
1.1.98.3 ethyl {2-[(1,3-benzothiazole-2-carbonyl)amino]thiophene-3-carbonyl}carbamate
-
 Mycobacterium tuberculosis
1.1.98.3 N-[2-(4-methoxyphenoxy)ethyl]-3,5-dinitrobenzamide
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.98.3 trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD Mycobacterium tuberculosis
-
 trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.98.3 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.98.3 additional information the enzyme can use synthetic electron acceptors such as 2,6-dichlorophenolindophenol with good efficiency Mycobacterium tuberculosis ?
-
 ?
1.1.98.3 trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD
-
 Mycobacterium tuberculosis trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.98.3 decaprenylphosphoryl-D-ribose oxidase
-
 Mycobacterium tuberculosis
1.1.98.3 DprE1
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.98.3 FAD
-
 Mycobacterium tuberculosis