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Literature summary extracted from

  • Wang, H.; Xiao, D.; Zhou, C.; Wang, L.; Wu, L.; Lu, Y.; Xiang, Q.; Zhao, K.; Li, X.; Ma, M.
    YLL056C from Saccharomyces cerevisiae encodes a novel protein with aldehyde reductase activity (2017), Appl. Microbiol. Biotechnol., 101, 4507-4520.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.1 37.65
-
 formaldehyde pH 7.0, 30°C Saccharomyces cerevisiae
1.1.1.1 41.4
-
 propanal pH 7.0, 30°C Saccharomyces cerevisiae
1.1.1.1 42.74
-
 furfural pH 7.0, 30°C Saccharomyces cerevisiae
1.1.1.1 71.98
-
 Butanal pH 7.0, 30°C Saccharomyces cerevisiae
1.1.1.1 88.32
-
 glycolaldehyde pH 7.0, 30°C Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.1 cytoplasm
-
 Saccharomyces cerevisiae 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.1 Ca2+ 0.5 mM, substrate glycolaldehyde, 86.2% residual activity Saccharomyces cerevisiae
1.1.1.1 Cu2+ 0.25 mM, substrate glycolaldehyde, no residual activity Saccharomyces cerevisiae
1.1.1.1 Fe3+ 0.5 mM, substrate glycolaldehyde, 92.2% residual activity Saccharomyces cerevisiae
1.1.1.1 Mg2+ 0.5 mM, substrate glycolaldehyde, 93.5% residual activity Saccharomyces cerevisiae
1.1.1.1 Mn2+ 0.5 mM, substrate glycolaldehyde, 89% residual activity Saccharomyces cerevisiae
1.1.1.1 Ni2+ 0.5 mM, substrate glycolaldehyde, 54.9% residual activity Saccharomyces cerevisiae
1.1.1.1 Zn2+ 0.5 mM, substrate glycolaldehyde, 32.9% residual activity Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.1 Saccharomyces cerevisiae
-
-
-
1.1.1.1 Saccharomyces cerevisiae BY47420
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.1 0.44
-
 substrate formaldehyde, pH 7.0, 30°C Saccharomyces cerevisiae
1.1.1.1 0.47
-
 substrate furfural, pH 7.0, 30°C Saccharomyces cerevisiae
1.1.1.1 6.5
-
 substrate glycolaldehyde, pH 7.0, 30°C Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.1 butanal + NADH
-
 Saccharomyces cerevisiae n-butanol + NAD+
-
 ?
1.1.1.1 butanal + NADH
-
 Saccharomyces cerevisiae BY47420 n-butanol + NAD+
-
 ?
1.1.1.1 formaldehyde + NADH + H+
-
 Saccharomyces cerevisiae methanol + NAD+
-
 ?
1.1.1.1 formaldehyde + NADH + H+
-
 Saccharomyces cerevisiae BY47420 methanol + NAD+
-
 ?
1.1.1.1 furfural + NADH + H+
-
 Saccharomyces cerevisiae furfuryl alcohol + NAD+
-
 ?
1.1.1.1 furfural + NADH + H+
-
 Saccharomyces cerevisiae BY47420 furfuryl alcohol + NAD+
-
 ?
1.1.1.1 glycolaldehyde + NADH + H+
-
 Saccharomyces cerevisiae glycol + NAD+
-
 ?
1.1.1.1 glycolaldehyde + NADH + H+
-
 Saccharomyces cerevisiae BY47420 glycol + NAD+
-
 ?
1.1.1.1 isobutyraldehyde + NADH + H+
-
 Saccharomyces cerevisiae isobutanol + NAD+
-
 ?
1.1.1.1 isobutyraldehyde + NADH + H+
-
 Saccharomyces cerevisiae BY47420 isobutanol + NAD+
-
 ?
1.1.1.1 propanal + NADH + H+
-
 Saccharomyces cerevisiae propanol + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.1 YLL056C
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.1 30
-
 reduction of formaldehyde Saccharomyces cerevisiae
1.1.1.1 35
-
 reduction of glycolaldehyde, furfural, butyraldehyde, and propionaldehyde Saccharomyces cerevisiae

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.1.1.1 25
-
 6 h, more than 90% residual activity Saccharomyces cerevisiae
1.1.1.1 45
-
 complete loss of activity within 6 h Saccharomyces cerevisiae

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.1.1.1 0.73
-
 propanal pH 7.0, 30°C Saccharomyces cerevisiae
1.1.1.1 1.28
-
 formaldehyde pH 7.0, 30°C Saccharomyces cerevisiae
1.1.1.1 1.58
-
 furfural pH 7.0, 30°C Saccharomyces cerevisiae
1.1.1.1 1.99
-
 Butanal pH 7.0, 30°C Saccharomyces cerevisiae
1.1.1.1 18.65
-
 glycolaldehyde pH 7.0, 30°C Saccharomyces cerevisiae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.1 6.5
-
 reduction of glycolaldehyde, furfural, formaldehyde, butyraldehyde, and propionaldehyde Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.1 additional information no activity with NADPH Saccharomyces cerevisiae
1.1.1.1 NADH
-
 Saccharomyces cerevisiae

Expression

EC Number Organism Comment Expression
1.1.1.1 Saccharomyces cerevisiae expression is significantly upregulated under high furfural (2-furaldehyde) or 5-(hydroxymethyl)-2-furaldehyde concentrations up

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
1.1.1.1 0.018
-
 propanal pH 7.0, 30°C Saccharomyces cerevisiae
1.1.1.1 0.028
-
 Butanal pH 7.0, 30°C Saccharomyces cerevisiae
1.1.1.1 0.034
-
 formaldehyde pH 7.0, 30°C Saccharomyces cerevisiae
1.1.1.1 0.034
-
 furfural pH 7.0, 30°C Saccharomyces cerevisiae
1.1.1.1 0.21
-
 glycolaldehyde pH 7.0, 30°C Saccharomyces cerevisiae