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Literature summary extracted from

  • Zhu, Q.; Cao, S.M.; Lin, H.X.; Yang, Q.; Liu, S.L.; Guo, L.
    Overexpression of acylglycerol kinase is associated with poorer prognosis and lymph node metastasis in nasopharyngeal carcinoma (2016), Tumour Biol., 37, 3349-3357.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.7.1.94 diagnostics overexpression of acylglycerol kinase is associated with poorer prognosis and lymph node metastasis in nasopharyngeal carcinoma and thus the enzyme has potential as a prognostic factor for overall survival in in nasopharyngeal carcinoma, and for lymph node metastasis in nasopharyngeal carcinoma Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.94 gene agk, quantitative real-time PCR expression analysis of AGK Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.94 ATP + acylglycerol Homo sapiens
-
 ADP + acyl-sn-glycerol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.94 Homo sapiens Q53H12 gene agk
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.94 5-8F cell
-
 Homo sapiens
-
2.7.1.94 6-10B cell
-
 Homo sapiens
-
2.7.1.94 CNE-1 cell
-
 Homo sapiens
-
2.7.1.94 CNE-2 cell
-
 Homo sapiens
-
2.7.1.94 HK-1 cell
-
 Homo sapiens
-
2.7.1.94 lymph node
-
 Homo sapiens
-
2.7.1.94 nasopharyngeal carcinoma cell enzyme AGK is significantly upregulated in NPC cell lines and clinical specimens as indicated by real-time PCR and Western blotting, overview Homo sapiens
-
2.7.1.94 nasopharyngeal epithelium primary, healthy Homo sapiens
-
2.7.1.94 NP-69 cell
-
 Homo sapiens
-
2.7.1.94 SUNE-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.94 ATP + acylglycerol
-
 Homo sapiens ADP + acyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.94 AGK
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.94 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.94 physiological function by acting as a lipid kinase, AGK catalyzes the phosphorylation of acylglycerol to generate lysophosphatidic acid , which is known to be involved in tumor progression, invasion, neovascularization, and metastasis. Overexpression of acylglycerol kinase is associated with poorer prognosis and lymph node metastasis in nasopharyngeal carcinoma. High expression of enzyme AGK is associated with significantly shorter overall and disease-free survival and is an independent prognostic factor for overall survival. High AGK expression is associated with lymph node metastasis and is an independent predicted factor for lymph node metastasis in nasopharyngeal carcinoma Homo sapiens