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Literature summary extracted from

  • He, L.; Wang, X.; Cui, P.; Jin, J.; Chen, J.; Zhang, W.; Zhang, Y.
    UbiA (Rv3806c) encoding DPPR synthase involved in cell wall synthesis is associated with ethambutol resistance in Mycobacterium tuberculosis (2015), Tuberculosis, 95, 149-154.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.4.2.45 F176L the mutation is associated with ethambutol resistance Mycobacterium tuberculosis
2.4.2.45 K174T the mutation is associated with ethambutol resistance Mycobacterium tuberculosis
2.4.2.45 W175C the mutation is associated with ethambutol resistance Mycobacterium tuberculosis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.45 membrane
-
 Mycobacterium tuberculosis 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.45 trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate Mycobacterium tuberculosis
-
 trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate
-
 ?
2.4.2.45 trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate Mycobacterium tuberculosis H37Rv
-
 trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.45 Mycobacterium tuberculosis P9WFR5
-
-
2.4.2.45 Mycobacterium tuberculosis H37Rv P9WFR5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.45 trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Mycobacterium tuberculosis trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate
-
 ?
2.4.2.45 trans,octacis-decaprenyl phosphate + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Mycobacterium tuberculosis H37Rv trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.45 DPPR synthase
-
 Mycobacterium tuberculosis
2.4.2.45 Rv3806c
-
 Mycobacterium tuberculosis
2.4.2.45 ubiA
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
2.4.2.45 physiological function overexpression of the wild type enzyme leads to increased resistance to ethambutol in Mycobaterium tuberculosis Mycobacterium tuberculosis