Literature summary extracted from

Tian, K.; Liu, Z.; Wang, J.; Xu, S.; You, T.; Liu, P.
Sirtuin-6 inhibits cardiac fibroblasts differentiation into myofibroblasts via inactivation of nuclear factor kappaB signaling (2015), Transl. Res., 165, 374-386.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.1.B41	Rattus norvegicus	Q4FZY2	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.3.1.B41	cardiac fibroblast	-	Rattus norvegicus	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.3.1.B41	SIRT6	-	Rattus norvegicus
2.3.1.B41	sirtuin-6	-	Rattus norvegicus

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.3.1.B41	NAD+	dependent on	Rattus norvegicus

Expression

EC Number	Organism	Comment	Expression
2.3.1.B41	Rattus norvegicus	SIRT6 expression is upregulated under pathologic conditions in angiotensin II-stimulated cardiac fibroblasts and in myocardium of rat subjected to abdominal aortic constriction surgery	up

General Information

EC Number	General Information	Comment	Organism
2.3.1.B41	malfunction	SIRT6 depletion in cardiac fibroblasts results in increased cell proliferation and extracellular matrix deposition as well as significantly higher expression of alpha-smooth muscle actin, the classical marker of myofibroblast differentiation, and increased formation of focal adhesions. Notably, SIRT6 depletion further exacerbates angiotensin IIinduced myofibroblast differentiation	Rattus norvegicus
2.3.1.B41	physiological function	the enzyme is a key modulator in the phenotypic conversion of cardiac fibroblasts to myofibroblasts	Rattus norvegicus

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Release 2023.1 (January 2023)