Literature summary extracted from

Yamashita, S.; Tomita, K.
Mechanism of 3-matured tRNA discrimination from 3-immature tRNA by class-II CCA-adding enzyme (2016), Structure, 24, 918-925.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.7.72	Thermotoga maritima	Q9WZH4	-	-
2.7.7.72	Thermotoga maritima DSM 3109	Q9WZH4	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.7.72	TM_0715	-	Thermotoga maritima

General Information

EC Number	General Information	Comment	Organism
2.7.7.72	physiological function	enzyme terminates RNA synthesis after completion of 3'-CCA addition, and discriminates 3'-mature tRNA from 3'-immature tRNA. After completion of 3'-CCA addition at the catalytic site, the 3'-CCA refolds and relocates to the release site, which is discrete from the catalytic site. The 3'-CCA forms a continuously stacked, stable conformation together with the enzyme. Consequently, the 3'-mature tRNA rotates relative to the surface of the enzyme, and only the 3'-mature tRNA is ready for release. The 3'-regions of immature tRNAs cannot form the stable stacking conformation in the release site. Thus, the 3' end is relocated in the catalytic site, and the 3'-CCA is reconstructed	Thermotoga maritima

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Release 2023.1 (January 2023)