Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Nagahara, N.; Nagano, M.; Ito, T.; Shimamura, K.; Akimoto, T.; Suzuki, H.
    Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: a model for human mercaptolactate-cysteine disulfiduria (2013), Sci. Rep., 3, 1986.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.1.2 cytoplasm
-
 Mus musculus 5737
-
2.8.1.2 mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.1.2 3-mercaptopyruvate + cyanide Mus musculus
-
 pyruvate + thiocyanate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.1.2 Mus musculus Q99J99
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.1.2 cerebellum
-
 Mus musculus
-
2.8.1.2 cerebrum
-
 Mus musculus
-
2.8.1.2 kidney
-
 Mus musculus
-
2.8.1.2 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.1.2 3-mercaptopyruvate + cyanide
-
 Mus musculus pyruvate + thiocyanate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.1.2 MST
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.8.1.2 malfunction 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors with an increase in serotonin level in the prefrontal cortex, but not with abnormal morphological changes in the brain Mus musculus
2.8.1.2 metabolism the enzyme functions as an antioxidant protein and can produce H2S (or HS2) and SOx Mus musculus