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Literature summary extracted from

  • Minchenko, D.; Lypova, N.; Harmash, Y.; Kulinich, A.; Marunych, R.; Karbovskyi, L.; Minchenko, O.
    Expression of genes encoded 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and 6-phosphofructo-1-kinase in U87 glioma cells with ERN1 loss of function: hypoxic regulation (2013), Res. J. Pharm. Biol. Chem. Sci., 4, 28-42.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.105 gene PFKFB1, expression analysis Homo sapiens
2.7.1.105 gene PFKFB2, expression analysis Homo sapiens
2.7.1.105 gene PFKFB3, expression analysis Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.105 Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.105 ATP + beta-D-fructose 6-phosphate Homo sapiens
-
 ADP + beta-D-fructose 2,6-bisphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.105 Homo sapiens O60825 gene/isozyme PFKFB2
-
2.7.1.105 Homo sapiens P16118 gene/isozyme Pfkfb1
-
2.7.1.105 Homo sapiens Q16875 gene/isozyme PFKFB3
-
2.7.1.105 Homo sapiens Q16877 gene/isozyme Pfkfb1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.105 glioma cell
-
 Homo sapiens
-
2.7.1.105 U-87 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.105 ATP + beta-D-fructose 6-phosphate
-
 Homo sapiens ADP + beta-D-fructose 2,6-bisphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.105 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase
-
 Homo sapiens
2.7.1.105 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
 Homo sapiens
2.7.1.105 PFKFB1
-
 Homo sapiens
2.7.1.105 PFKFB2
-
 Homo sapiens
2.7.1.105 PFKFB3
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.105 ATP
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.1.105 Homo sapiens in cells with ERN1 loss of function decreases PFKFB2 mRNA down
2.7.1.105 Homo sapiens ERN1 loss of function and hypoxic conditions do not affect PFKFB1 mRNA levels additional information
2.7.1.105 Homo sapiens hypoxic conditions do not affect PFKFB2 mRNA levels additional information
2.7.1.105 Homo sapiens blocking the function of ERN1 enzyme, the key endoplasmic reticulum stress sensor, leads to an increase in the expression levels of PFKFB1, PFKFB2, PFKFB3 and PFKFB4 mRNA, being more significant for PFKFB4 and PFKFB2 up
2.7.1.105 Homo sapiens blocking the function of ERN1 enzyme, the key endoplasmic reticulum stress sensor, leads to an increase in the expression levels of PFKFB1, PFKFB2, PFKFB3 and PFKFB4 mRNA, being more significant for PFKFB4 and PFKFB2. Hypoxic conditions leads to an increase of the expression level of PFKFB3 and PFKFB4 mRNA both in control glioma cells and cells with ERN1 loss of function, being more significant for PFKFB4. The blockade of ERN1 signaling enzyme function decreases the effect of hypoxia on the expression level of both PFKFB3 and PFKFB4 mRN up

General Information

EC Number General Information Comment Organism
2.7.1.105 metabolism expression level of some PFKFB and PFK1 genes in normoxic and hypoxic conditions in glioma cells is mediated by ERN1 signaling system of endoplasmic reticulum stress. Effect of hypoxia on the expression of genes encoded different 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1, PFKFB2, PFKFB3 and PFKFB4) and 6-phosphofructo-1-kinase (PFKL, PFKM and PFKP) as well as lactate dehydrogenase in glioma U-87 cells and its subline with suppressed function of ERN1 signaling enzyme, overview Homo sapiens
2.7.1.105 metabolism expression level of some PFKFB and PFK1 genes in normoxic and hypoxic conditions in glioma cells is mediated by ERN1 signaling system of endoplasmic reticulum stress. Effect of hypoxia on the expression of genes encoded different 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB1, PFKFB2, PFKFB3 and PFKFB4) and 6-phosphofructo-1-kinase (PFKL, PFKM and PFKP) as well as lactate dehydrogenase in glioma U-87 cells and its subline with suppressed function of ERN1 signaling enzyme, overview. Increased expression of PFKFB3 and PFKFB4 under hypoxic conditions correlates with strong induction of PFKL expression in control glioma cells only Homo sapiens