Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Yu, Y.; Zhang, H.; Guo, F.; Sun, M.; Zhu, G.
    A unique hexokinase in Cryptosporidium parvum, an apicomplexan pathogen lacking the Krebs cycle and oxidative phosphorylation (2014), Protist, 165, 701-714.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.1 2-deoxy-D-glucose competitive, compound also inhibits the parasite growth in vitro at concentrations nontoxic to host cells Cryptosporidium parvum

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.1 0.109
-
 D-mannose pH 7.5, temperature not specified in the publication Cryptosporidium parvum
2.7.1.1 0.183
-
 D-glucose pH 7.5, temperature not specified in the publication Cryptosporidium parvum
2.7.1.1 0.673
-
 ATP pH 7.5, temperature not specified in the publication Cryptosporidium parvum
2.7.1.1 6.49
-
 D-fructose pH 7.5, temperature not specified in the publication Cryptosporidium parvum

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.1 Cryptosporidium parvum Q5CWT5
-
-
2.7.1.1 Cryptosporidium parvum Iowa II Q5CWT5
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.1 additional information gene is expressed in all life cycle stages Cryptosporidium parvum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.1 ATP + D-fructose
-
 Cryptosporidium parvum ADP + D-fructose 6-phosphate 8.6% of the activity with ATP ?
2.7.1.1 ATP + D-fructose
-
 Cryptosporidium parvum Iowa II ADP + D-fructose 6-phosphate 8.6% of the activity with ATP ?
2.7.1.1 ATP + D-glucose ATP is the preferred nucleside triphosphate Cryptosporidium parvum ADP + D-glucose 6-phosphate
-
 ?
2.7.1.1 ATP + D-glucose ATP is the preferred nucleside triphosphate Cryptosporidium parvum Iowa II ADP + D-glucose 6-phosphate
-
 ?
2.7.1.1 ATP + D-mannose
-
 Cryptosporidium parvum ADP + D-mannose 6-phosphate 52% of the activity with ATP ?
2.7.1.1 ATP + D-mannose
-
 Cryptosporidium parvum Iowa II ADP + D-mannose 6-phosphate 52% of the activity with ATP ?
2.7.1.1 CTP + D-glucose
-
 Cryptosporidium parvum CDP + D-glucose 6-phosphate
-
 ?
2.7.1.1 CTP + D-glucose
-
 Cryptosporidium parvum Iowa II CDP + D-glucose 6-phosphate
-
 ?
2.7.1.1 additional information no substrates: D-galactose, sorbose. TTP, UTP, CTP and GTP show 6.5%-17.1% of the activity with ATP Cryptosporidium parvum ?
-
 ?
2.7.1.1 additional information no substrates: D-galactose, sorbose. TTP, UTP, CTP and GTP show 6.5%-17.1% of the activity with ATP Cryptosporidium parvum Iowa II ?
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.1.1 0.02
-
 D-fructose pH 7.5, temperature not specified in the publication Cryptosporidium parvum
2.7.1.1 9.5
-
 ATP pH 7.5, temperature not specified in the publication Cryptosporidium parvum
2.7.1.1 12.1
-
 D-mannose pH 7.5, temperature not specified in the publication Cryptosporidium parvum
2.7.1.1 20.5
-
 D-glucose pH 7.5, temperature not specified in the publication Cryptosporidium parvum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.1.1 0.34
-
 2-deoxy-D-glucose pH 7.5, temperature not specified in the publication Cryptosporidium parvum

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.1 5.75
-
 pH 7.5, temperature not specified in the publication Cryptosporidium parvum 2-deoxy-D-glucose