EC Number | Cloned (Comment) | Organism |
---|---|---|
2.5.1.47 | gene cysl-2, quantitative real-time PCR enzyme expression analysis | Caenorhabditis elegans |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.47 | additional information | Caenorhabditis elegans | the enzyme shows H2S synthesizing activity, cysteine synthase activity and also L-3-cyanoalanine synthase activity, EC 4.4.1.9 | ? | - |
? | |
2.5.1.47 | O-acetyl-L-serine + hydrogen sulfide | Caenorhabditis elegans | - |
L-cysteine + acetate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.47 | Caenorhabditis elegans | O45679 | gene cysl-2 or K10H10.2, and gene GYY4137 | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.47 | additional information | the enzyme shows H2S synthesizing activity, cysteine synthase activity and also L-3-cyanoalanine synthase activity, EC 4.4.1.9 | Caenorhabditis elegans | ? | - |
? | |
2.5.1.47 | O-acetyl-L-serine + hydrogen sulfide | - |
Caenorhabditis elegans | L-cysteine + acetate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.5.1.47 | CysK2 | - |
Caenorhabditis elegans |
2.5.1.47 | CYSL | - |
Caenorhabditis elegans |
2.5.1.47 | cysl-2 | - |
Caenorhabditis elegans |
2.5.1.47 | GYY4137 | - |
Caenorhabditis elegans |
2.5.1.47 | sulfhydrylase/cysteine synthase | - |
Caenorhabditis elegans |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.47 | pyridoxal 5'-phosphate | - |
Caenorhabditis elegans |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.5.1.47 | malfunction | cysl-2 mutant phenotype, overview. The cysl-2 mutant has a reduced rate of enzymatic H2S synthesis from the added substrates L-cysteine and is marked by a decline in reproductive output compared to wild-type worms. Body area and length are significantly lower in cysl-2 compared to age-matched wild type worms, and GYY4137 treatment effectively rescues this phenotype. Lifespan is reduced in cysl-2 compared to wild-type and the addition of GYY4137 reverses this effect and increases the median survival of cysl-2 | Caenorhabditis elegans |
2.5.1.47 | physiological function | the bifunctional enzyme, encoded by gene K10H10.2, or cysl-2, shows cysteine synthase activity and also L-3-cyanoalanine synthase activity, EC 4.4.1.9. It has been described as a hypoxia inducible factor (HIF) target. The enzyme regulates the mRNA expression of aging-associated and stress-related genes in wild-type Caenorhabditis elegans. Enzyme treatment protects the wild-type nematodes against oxidative, endoplasmic reticulum stress, and thermal stressors but not cadmium-induced metallic stress. The enzyme is active in vitro and in vivo and protects against lipopolysaccharide-induced inflammation. GYY4137 induces longevity and stress resistance, mechanism of action via induction of T24B8.5 and altered transcriptional control of SKN-1 | Caenorhabditis elegans |