EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.105 | ATP + beta-D-fructose 6-phosphate | Mus musculus | - |
ADP + beta-D-fructose 2,6-bisphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.105 | Mus musculus | P70265 | gene Pfkfb2 | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.105 | heart | heart PFK-2 isozyme | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.105 | ATP + beta-D-fructose 6-phosphate | - |
Mus musculus | ADP + beta-D-fructose 2,6-bisphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.105 | Pfk-2 | - |
Mus musculus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.105 | ATP | - |
Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.105 | malfunction | Mb transgenic mice have reduced fructose 2,6-bisphosphate levels, due to cardiac expression of a transgene for a mutant, kinase deficient form of the enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2) which controls the level of fructose 2,6-bisphosphate. Mb hearts are markedly more sensitive to transverse aortic constriction-induced damage showing lower fractional shortening in Mb-TAC mice as well as larger left ventricular end diastolic and end systolic diameters. Cardiac hypertrophy and pulmonary congestion are more severe in Mb-transverse aortic constriction mice, Mb transgene exacerbates transverse aortic constriction-induced increases in cardiac hypertrophy and lung weight, detailed phenotype, overview | Mus musculus |
2.7.1.105 | physiological function | fructose 2,6-bisphosphate is a positive regulator of the glycolytic enzyme phosphofructokinase | Mus musculus |