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Literature summary extracted from

  • Pan, Y.; Ni, R.; Deng, Q.; Huang, X.; Zhang, Y.; Lu, C.; Li, F.; Huang, D.; He, S.; Chen, B.
    Glyoxylate reductase/hydroxypyruvate reductase: a novel prognostic marker for hepatocellular carcinoma patients after curative resection (2013), Pathobiology, 80, 155-162.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.26 diagnostics enzyme glyoxylate reductase/hydroxypyruvate reductase is a prognostic marker for hepatocellular carcinoma patients after curative resection. Patients with negative GRHPR both in tumor tissues and nontumoral tissues have a significantly shorter survival time than those with positive GRHPR. Multivariate analysis establishes that GRHPR is detected in nontumoral tissues as an independent prognostic factor for patients with hepatocellular carcinoma, overview Homo sapiens
1.1.1.29 medicine glyoxylate reductase/hydroxypyruvate reductase is a prognostic marker for hepatocellular carcinoma patients after curative resection Homo sapiens
1.1.1.79 diagnostics enzyme glyoxylate reductase/hydroxypyruvate reductase is a prognostic marker for hepatocellular carcinoma patients after curative resection. Patients with negative GRHPR both in tumor tissues and nontumoral tissues have a significantly shorter survival time than those with positive GRHPR. Multivariate analysis establishes that GRHPR is detected in nontumoral tissues as an independent prognostic factor for patients with hepatocellular carcinoma, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.29 hydroxypyruvate + NADH + H+ Homo sapiens
-
 D-glycerate + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.26 Homo sapiens Q9UBQ7
-
-
1.1.1.29 Homo sapiens
-
-
-
1.1.1.79 Homo sapiens Q9UBQ7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.26 HEP-3B cell
-
 Homo sapiens
-
1.1.1.26 Hep-G2 cell
-
 Homo sapiens
-
1.1.1.26 hepatocellular carcinoma cell enzyme GRHPR is lost in hepatocellular carcinoma (HCC) and proliferative HCC cells Homo sapiens
-
1.1.1.26 HL-7702 cell
-
 Homo sapiens
-
1.1.1.26 Huh-7 cell GRHPR is reduced in proliferative Huh7 cells Homo sapiens
-
1.1.1.26 additional information immunohistochemic tissue expression analysis of GRHPR, overview. GRHPR shows a lower expression in tumor tissues than in nontumoral tissues. GRHPR is negatively correlated with Ki-67 Homo sapiens
-
1.1.1.26 SMMC-7721 cell
-
 Homo sapiens
-
1.1.1.29 HEP-3B cell
-
 Homo sapiens
-
1.1.1.29 Hep-G2 cell
-
 Homo sapiens
-
1.1.1.29 hepatocellular carcinoma cell
-
 Homo sapiens
-
1.1.1.29 Huh-7 cell
-
 Homo sapiens
-
1.1.1.29 liver
-
 Homo sapiens
-
1.1.1.29 SMMC-7721 cell
-
 Homo sapiens
-
1.1.1.79 HEP-3B cell
-
 Homo sapiens
-
1.1.1.79 Hep-G2 cell
-
 Homo sapiens
-
1.1.1.79 hepatocellular carcinoma cell enzyme GRHPR is lost in hepatocellular carcinoma (HCC) and proliferative HCC cells Homo sapiens
-
1.1.1.79 HL-7702 cell
-
 Homo sapiens
-
1.1.1.79 Huh-7 cell GRHPR is reduced in proliferative Huh7 cells Homo sapiens
-
1.1.1.79 additional information immunohistochemic tissue expression analysis of GRHPR, overview. GRHPR shows a lower expression in tumor tissues than in nontumoral tissues. GRHPR is negatively correlated with Ki-67 Homo sapiens
-
1.1.1.79 SMMC-7721 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.29 hydroxypyruvate + NADH + H+
-
 Homo sapiens D-glycerate + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.26 glyoxylate reductase/hydroxypyruvate reductase
-
 Homo sapiens
1.1.1.26 GRHPR
-
 Homo sapiens
1.1.1.29 GRHPR bifunctional enzyme with glyoxylate reductase and hydroxypyruvate reductase activities Homo sapiens
1.1.1.79 glyoxylate reductase/hydroxypyruvate reductase
-
 Homo sapiens
1.1.1.79 GRHPR
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.29 NADH
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.1.1.29 Homo sapiens enzyme expression is decreased or lost in hepatocellular carcinoma down

General Information

EC Number General Information Comment Organism
1.1.1.26 malfunction enzyme deficiency causes primary hyperoxaluria type 2 Homo sapiens
1.1.1.26 metabolism glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is a key enzyme in the glyoxylate cycle Homo sapiens
1.1.1.79 malfunction enzyme deficiency causes primary hyperoxaluria type 2 Homo sapiens
1.1.1.79 metabolism glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is a key enzyme in the glyoxylate cycle Homo sapiens