Literature summary extracted from

Liu, J.; Zheng, W.
Cyclic peptide-based potent human SIRT6 inhibitors (2016), Org. Biomol. Chem., 14, 5928-5935.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.3.1.B41	H2N-AK-(N(epsilon)-thioacetyl-)lysine-LM-COOH	moderate potent inhibitor	Homo sapiens
2.3.1.B41	H2N-HK-(N(epsilon)-thioacetyl-)lysine-LM-COOH	moderate potent inhibitor	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.3.1.B41	NAD+ + [histone H3]-N6-acetyl-L-lysine9	Homo sapiens	-	nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.3.1.B41	Homo sapiens	Q8N6T7	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.3.1.B41	NAD+ + [histone H3]-N6-acetyl-L-lysine9	-	Homo sapiens	nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.3.1.B41	SIRT6	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.3.1.B41	NAD+	dependent on	Homo sapiens

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Release 2023.1 (January 2023)