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Literature summary extracted from

  • Xie, Y.; Li, Y.; Peng, X.; Peng, X.; Henderson, F.; Deng, L.; Chen, N.
    Ikappa B kinase alpha involvement in the development of nasopharyngeal carcinoma through a NF-kappaB-independent and ERK-dependent pathway (2013), Oral Oncol., 49, 1113-1120.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein] Homo sapiens
-
 ADP + [IkappaB phosphoprotein]
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.10 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.10 nasopharyngeal carcinoma cell
-
 Homo sapiens
-
2.7.11.10 NP-69-SV40T cell
-
 Homo sapiens
-
2.7.11.10 SUNE-1 cell
-
 Homo sapiens
-
2.7.11.10 SUNE-1-5-8F cell
-
 Homo sapiens
-
2.7.11.10 SUNE-1-6-10B cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.10 ATP + [IkappaB protein]
-
 Homo sapiens ADP + [IkappaB phosphoprotein]
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.10 Ikappa B kinase alpha
-
 Homo sapiens
2.7.11.10 IKKalpha
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.11.10 Homo sapiens the enzyme is underexpressed in highly invasive SUNE-1-5-8F cells compared with non-invasive cells (SUNE-1 and SUNE-6-10B) down

General Information

EC Number General Information Comment Organism
2.7.11.10 physiological function increase in enzyme expression suppresses the progression of nasopharyngeal carcinoma through a nuclear factor-kappaB-independent and extracellular signal-regulated kinase-dependent pathway Homo sapiens