EC Number | Application | Comment | Organism |
---|---|---|---|
2.7.7.1 | medicine | NMNAT1 is a potential therapeutic target for stroke | Mus musculus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.7.7.1 | additional information | NMNAT1 overexpression reduces brain infarction size and improves behavioral outcomes in mice with ischemic stroke | Mus musculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.7.1 | ATP + nicotinamide ribonucleotide | Mus musculus | - |
diphosphate + NAD+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.7.1 | Mus musculus | Q9EPA7 | gene Nmnat1 | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.7.1 | brain cortex | - |
Mus musculus | - |
2.7.7.1 | neuron | - |
Mus musculus | - |
2.7.7.1 | neuronal cell line | - |
Mus musculus | - |
2.7.7.1 | primary cell line | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.7.1 | ATP + nicotinamide ribonucleotide | - |
Mus musculus | diphosphate + NAD+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.7.1 | nicotinamide mononucleotide adenylyltransferase 1 | - |
Mus musculus |
2.7.7.1 | NMNAT1 | - |
Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.7.1 | malfunction | NMNAT1 overexpression reduces cell death and apoptosis both in vitro and in vivo. NMNAT1 knockdown exacerbates cell death and apoptosis. NMNAT1 overexpression regulates neuron survival via AMPK activation, as NMNAT1 overexpression enhances AMPKactivity in OGD-treated cortical neurons, and AMPK inhibitor blocks LV-NMNAT1-induced neuroprotection in OGD-treated cortical neurons | Mus musculus |
2.7.7.1 | physiological function | isozyme nicotinamide mononucleotide adenylyltransferase 1 protects neural cells against ischemic injury in primary cultured neuronal cells and mouse brain with ischemic stroke through AMP-activated protein kinase activation. NMNAT1 overexpression reduces brain infarction size and improves behavioral outcomes in mice with ischemic stroke. Role and mechanism of NMNAT1 in the regulation of neural ischemic injuries by using cultured cortical neurons with oxygen-glucose deprivation of ischemic injury in vitro and mouse transient middle cerebral artery occlusion (MCAO) model of stroke in vivo, overview | Mus musculus |