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Literature summary extracted from

  • Zhang, X.; Khan, S.; Jiang, H.; Antonyak, M.A.; Chen, X.; Spiegelman, N.A.; Shrimp, J.H.; Cerione, R.A.; Lin, H.
    Identifying the functional contribution of the defatty-acylase activity of SIRT6 (2016), Nat. Chem. Biol., 12, 614-620.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.B41 expressed in Escherichia coli BL21(DE3) and NIH-3T3 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.B41 G60A the mutant is a lysine defatty acylase in vitro with substantially decreased deacetylase activity in vitro and no detectable deacetylase activity in cells Homo sapiens
2.3.1.B41 H133Y inactive Homo sapiens
2.3.1.B41 R65A the mutant shows only ADP-ribosyltransferase activity but no deacetylase activity Homo sapiens
2.3.1.B41 S56Y inactive Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.B41 Homo sapiens Q8N6T7
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.B41
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.B41 NAD+ + [histone H3]-N6-acetyl-L-lysine9
-
 Homo sapiens nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose
-
 ?
2.3.1.B41 NAD+ + [histone H3]-N6-myristoyl-L-lysine
-
 Homo sapiens nicotinamide + [histone H3]-L-lysine + 2'-O-myristoyl-ADP ribose
-
 ?
2.3.1.B41 NAD+ + [histone H3]-N6-palmitoyl-L-lysine
-
 Homo sapiens nicotinamide + [histone H3]-L-lysine + 2'-O-palmitoyl-ADP ribose
-
 ?
2.3.1.B41 NAD+ + [tumor necrosis factor-alpha]-N6-acetyl-L-lysine9
-
 Homo sapiens nicotinamide + [tumor necrosis factor-alpha]-L-lysine + 2'-O-acetyl-ADP ribose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.B41 SIRT6
-
 Homo sapiens
2.3.1.B41 sirtuin 6
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.B41 NAD+ dependent on Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.B41 metabolism the enzyme promotes TNF-alpha secretion by defatty acylation Homo sapiens