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Literature summary extracted from

  • Tuan, P.; Zhao, S.; Kim, J.; Kim, Y.; Yang, J.; Li, C.; Kim, S.; Arasu, M.; Al-Dhabi, N.; Park, S.
    Riboflavin accumulation and molecular characterization of cDNAs encoding bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase, lumazine synthase, and riboflavin synthase in different organs of Lycium chinense plant (2014), Molecules, 19, 17141-17153.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.78 gene LcLS1, DNA and amino acid sequence determination and analysis, sequence comparisons, quantitative real-time PCR expression analysis Lycium chinense
2.5.1.78 gene LcLS2, DNA and amino acid sequence determination and analysis, sequence comparisons, quantitative real-time PCR expression analysis Lycium chinense

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.78 25070
-
-
 Lycium chinense
2.5.1.78 25410
-
-
 Lycium chinense

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.9 6,7-dimethyl-8-(1-D-ribityl)lumazine Lycium chinense
-
 riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine
-
 ?
2.5.1.78 1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil Lycium chinense
-
 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.9 Lycium chinense W0FI48
-
-
2.5.1.78 Lycium chinense W0FEU6 cv. Cheongmyeong, gene LcLS2
-
2.5.1.78 Lycium chinense W0FJR2 cv. Cheongmyeong, gene LcLS1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.9 flower
-
 Lycium chinense
-
2.5.1.9 fruit highest expression in red fruits Lycium chinense
-
2.5.1.9 leaf
-
 Lycium chinense
-
2.5.1.9 root
-
 Lycium chinense
-
2.5.1.9 stem
-
 Lycium chinense
-
2.5.1.78 flower
-
 Lycium chinense
-
2.5.1.78 fruit green fruits, and red fruits Lycium chinense
-
2.5.1.78 leaf
-
 Lycium chinense
-
2.5.1.78 additional information the enzyme is constitutively expressed in all organs examined with the highest expression levels in leaves, lower expression in roots,, stems, and flowers, very low in green fruits Lycium chinense
-
2.5.1.78 additional information the isozyme LcLS2 is constitutively expressed in all organs examined with the highest expression levels in red fruits, low expression levels in green fruits and roots Lycium chinense
-
2.5.1.78 root
-
 Lycium chinense
-
2.5.1.78 stem
-
 Lycium chinense
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.9 6,7-dimethyl-8-(1-D-ribityl)lumazine
-
 Lycium chinense riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine
-
 ?
2.5.1.78 1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil
-
 Lycium chinense 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.78 ? x * 25070, LcLS1, sequence calculation Lycium chinense
2.5.1.78 ? x * 25410, LcLS2, sequence calculation Lycium chinense

Synonyms

EC Number Synonyms Comment Organism
2.5.1.9 riboflavin synthetase
-
 Lycium chinense
2.5.1.78 LcLS1
-
 Lycium chinense
2.5.1.78 LcLS2
-
 Lycium chinense
2.5.1.78 lumazine synthase
-
 Lycium chinense

General Information

EC Number General Information Comment Organism
2.5.1.78 metabolism lumazine synthase is involved in the riboflavin biosynthetic pathway and catalyzes the condensation of 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione with 3,4-dihydroxy-2-butanone-4-phosphate, which is obtained from ribulose 5-phosphate by 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBPS), yielding 6,7-dimethyl-8-ribityllumazine. Proposd riboflavin biosynthetic pathway in plants, overview Lycium chinense
2.5.1.78 additional information the enzyme carries an N-terminal extension typical for plant riboflavin biosynthetic proteins Lycium chinense