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Literature summary extracted from

  • Shi, X.; Cheng, Q.; Xu, L.; Yan, J.; Jiang, M.; He, J.; Xu, M.; Stefanovic-Racic, M.; Sipula, I.; ODoherty, R.M.; Ren, S.; Xie, W.
    Cholesterol sulfate and cholesterol sulfotransferase inhibit gluconeogenesis by targeting hepatocyte nuclear factor 4? (2014), Mol. Cell. Biol., 34, 485-497.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.2 Mus musculus O35400
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.2 Hepa1-6 cell
-
 Mus musculus
-
2.8.2.2 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.2 3'-phosphoadenylylsulfate + cholesterol
-
 Mus musculus adenosine 3',5'-bisphosphate + cholesterol sulfate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.2 cholesterol sulfotransferase
-
 Mus musculus
2.8.2.2 SULT2B1b
-
 Mus musculus

Expression

EC Number Organism Comment Expression
2.8.2.2 Mus musculus the expression of SULT2B1b in the liver is induced in obese mice and during the transition from the fasted to the fed state up

General Information

EC Number General Information Comment Organism
2.8.2.2 metabolism isoform SULT2B1b and its enzymatic by-product cholesterol sulfate are important metabolic regulators that control glucose metabolism. Mechanistically, cholesterol sulfate and SULT2B1b inhibit gluconeogenesis by suppressing the expression of acetyl coenzyme A synthetase, leading to decreased acetylation and nuclear exclusion of hepatocyte nuclear factor 4alpha. Mus musculus