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Literature summary extracted from

  • Wang, X.; Lin, C.; Zhao, X.; Liu, A.; Zhu, J.; Li, X.; Song, L.
    Acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor (2014), Mol. Cancer, 13, 106.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.94 gene agk, quantitative real-time PCR enzyme expression analysis Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.94 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.94 ATP + acylglycerol Homo sapiens
-
 ADP + acyl-sn-glycerol 3-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.94 Homo sapiens Q53H12 gene agk
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.94 breast cancer cell enzyme overexpression Homo sapiens
-
2.7.1.94 MCF-7 cell
-
 Homo sapiens
-
2.7.1.94 SKBR-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.94 ATP + acylglycerol
-
 Homo sapiens ADP + acyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.94 AGK
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.94 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.94 malfunction enzyme overexpression significantly enhances, whereas silencing endogenous enzyme AGK inhibits the proliferation and tumorigenicity of breast cancer cells both in vitro and in vivo. Overexpression of AGK enhances G1-S phase transition in breast cancer cells, which is associated with activation of AKT, suppression of FOXO1 transactivity, downregulation of cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1 and upregulation of the cell cycle regulator cyclin D1 Homo sapiens
2.7.1.94 physiological function acylglycerol kinase promotes cell proliferation and tumorigenicity in breast cancer via suppression of the FOXO1 transcription factor, FOXO1 is considered to be a tumor suppressor. The enzyme significantly correlates with patients' clinicopathologic characteristics, including clinical stage and tumor-nodule-metastasis (TNM) classification Homo sapiens