Literature summary extracted from

Bearson, S.M.; Bearson, B.L.; Lee, I.S.; Kich, J.D.
Polynucleotide phosphorylase (PNPase) is required for Salmonella enterica serovar Typhimurium colonization in swine (2013), Microb. Pathog., 65, 63-66.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.7.8	Salmonella enterica subsp. enterica serovar Typhimurium	-	-	-

General Information

EC Number	General Information	Comment	Organism
2.7.7.8	physiological function	the Pnp gene is required for Salmonella typhimurium virulence and gastrointestinal colonization of the natural swine host. Following intranasal inoculation, a significant increase in rectal temperature is observed in the pigs inoculated with wild-type Salmonella typhimurium compared to the pigs inoculated with the Pnp mutant. Fecal shedding of the Pnp mutant is significantly reduced during the 7-day study compared to the wild-type strain. Tissue colonization is also significantly reduced in the pigs inoculated with the pnp mutant, including the tonsils, ileocecal lymph nodes, Peyer's Patch region of the ileum, cecum and contents of the cecum	Salmonella enterica subsp. enterica serovar Typhimurium

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Release 2023.1 (January 2023)