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Literature summary extracted from

  • Ribitsch, D.; Zitzenbacher, S.; Augustin, P.; Schmoelzer, K.; Czabany, T.; Luley-Goedl, C.; Thomann, M.; Jung, C.; Sobek, H.; Mueller, R.; Nidetzky, B.; Schwab, H.
    High-quality production of human alpha-2,6-sialyltransferase in Pichia pastoris requires control over N-terminal truncations by host-inherent protease activities (2014), Microb. Cell Fact., 13, 138.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.3.1 expressed in Pichia pastoris strain KM71H Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.4.3.1 additional information the truncated enzyme DELTA108 is active as alpha2,6-sialyltransferase and CMP-N-acetylneuraminate hydrolase Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.3.1 40000
-
 x * 40000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.3.1 CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine Homo sapiens
-
 CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.1 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.1 CMP-N-acetylneuraminate + asialofetuin
-
 Homo sapiens ?
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
 Homo sapiens CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine
-
 ?
2.4.3.1 CMP-N-acetylneuraminate + lactosamine
-
 Homo sapiens ?
-
 ?
2.4.3.1 additional information no activity with 6'-sialyllactosamine Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.3.1 ? x * 40000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.4.3.1 alpha-2,6-sialyltransferase
-
 Homo sapiens
2.4.3.1 ST6Gal-I
-
 Homo sapiens