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Literature summary extracted from

  • Bosc, D.; Mouray, E.; Grellier, P.; Cojean, S.; Loiseau, P.; Dubois, J.
    Introduction of methionine mimics on 3-arylthiophene: Influence on protein farnesyltransferase inhibition and on antiparasitic activity (2013), MedChemComm, 4, 1034-1041.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.58 (2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-1-[2-(methylsulfanyl)ethyl]hydrazinyl)acetic acid
-
 Homo sapiens
2.5.1.58 (2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-1-[2-(methylsulfanyl)ethyl]hydrazinyl)acetic acid
-
 Trypanosoma brucei
2.5.1.58 (4S)-4-([[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]amino)-5-tert-butoxy-5-oxopentanoic acid
-
 Homo sapiens
2.5.1.58 (4S)-4-([[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]amino)-5-tert-butoxy-5-oxopentanoic acid
-
 Trypanosoma brucei
2.5.1.58 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)-N-adamantylthiophene-2-carboxamide
-
 Homo sapiens
2.5.1.58 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)-N-adamantylthiophene-2-carboxamide
-
 Trypanosoma brucei
2.5.1.58 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
-
 Homo sapiens
2.5.1.58 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
-
 Trypanosoma brucei
2.5.1.58 3-(4-chlorophenyl)-4-cyano-N'-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carbohydrazide
-
 Homo sapiens
2.5.1.58 3-(4-chlorophenyl)-4-cyano-N'-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carbohydrazide
-
 Trypanosoma brucei
2.5.1.58 3-(4-chlorophenyl)-4-cyano-N-(naphthalen-1-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide
-
 Homo sapiens
2.5.1.58 3-(4-chlorophenyl)-4-cyano-N-(naphthalen-1-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide
-
 Trypanosoma brucei
2.5.1.58 3-(4-chlorophenyl)-4-cyano-N-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide
-
 Homo sapiens
2.5.1.58 3-(4-chlorophenyl)-4-cyano-N-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide
-
 Trypanosoma brucei
2.5.1.58 3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
-
 Homo sapiens
2.5.1.58 3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
-
 Trypanosoma brucei
2.5.1.58 4-cyano-3-(3,4-dihydroxyphenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
-
 Homo sapiens
2.5.1.58 4-cyano-3-(3,4-dihydroxyphenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
-
 Trypanosoma brucei
2.5.1.58 4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
-
 Homo sapiens
2.5.1.58 4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
-
 Trypanosoma brucei
2.5.1.58 4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophene-2-carboxylic acid
-
 Homo sapiens
2.5.1.58 4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophene-2-carboxylic acid
-
 Trypanosoma brucei
2.5.1.58 5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophene-2-carboxylic acid
-
 Homo sapiens
2.5.1.58 5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophene-2-carboxylic acid
-
 Trypanosoma brucei
2.5.1.58 ethyl (2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-1-[2-(methylsulfanyl)ethyl]hydrazinyl)acetate
-
 Homo sapiens
2.5.1.58 ethyl (2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-1-[2-(methylsulfanyl)ethyl]hydrazinyl)acetate
-
 Trypanosoma brucei
2.5.1.58 ethyl 3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylate
-
 Homo sapiens
2.5.1.58 ethyl 3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylate
-
 Trypanosoma brucei
2.5.1.58 ethyl 4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylate
-
 Homo sapiens
2.5.1.58 ethyl 4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylate
-
 Trypanosoma brucei
2.5.1.58 ethyl N-(tert-butoxycarbonyl)-N-[2-(methylsulfanyl)ethyl]glycinate
-
 Homo sapiens
2.5.1.58 ethyl N-(tert-butoxycarbonyl)-N-[2-(methylsulfanyl)ethyl]glycinate
-
 Trypanosoma brucei
2.5.1.58 ethyl N-(tert-butoxycarbonyl)glycinate
-
 Homo sapiens
2.5.1.58 ethyl N-(tert-butoxycarbonyl)glycinate
-
 Trypanosoma brucei
2.5.1.58 ethyl [[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetate
-
 Homo sapiens
2.5.1.58 ethyl [[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetate
-
 Trypanosoma brucei
2.5.1.58 methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonothioyl]-D-methioninate
-
 Homo sapiens
2.5.1.58 methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonothioyl]-D-methioninate
-
 Trypanosoma brucei
2.5.1.58 methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-D-methioninate
-
 Homo sapiens
2.5.1.58 methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-D-methioninate
-
 Trypanosoma brucei
2.5.1.58 methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-isoleucyl-L-methioninate
-
 Homo sapiens
2.5.1.58 methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-isoleucyl-L-methioninate
-
 Trypanosoma brucei
2.5.1.58 methyl N-[[3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate
-
 Homo sapiens
2.5.1.58 methyl N-[[3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate
-
 Trypanosoma brucei
2.5.1.58 methyl N-[[4-cyano-3-(3,4-dihydroxyphenyl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate
-
 Homo sapiens
2.5.1.58 methyl N-[[4-cyano-3-(3,4-dihydroxyphenyl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate
-
 Trypanosoma brucei
2.5.1.58 methyl N-[[4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate
-
 Homo sapiens
2.5.1.58 methyl N-[[4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate
-
 Trypanosoma brucei
2.5.1.58 methyl N-[[4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophen-2-yl]carbonyl]-L-methioninate
-
 Homo sapiens
2.5.1.58 methyl N-[[4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophen-2-yl]carbonyl]-L-methioninate
-
 Trypanosoma brucei
2.5.1.58 methyl N-[[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]-L-methioninate
-
 Homo sapiens
2.5.1.58 methyl N-[[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]-L-methioninate
-
 Trypanosoma brucei
2.5.1.58 additional information addition of a methionine residue at position 2 of 3-arylthiophenes greatly improves enzyme inhibition, antiparasitic effect of the compounds on proliferation of 4 protozoan parasites, i.e. Plasmodium falciparum, Trypanosoma brucei brucei, Trypanosoma cruzi and Leishmania donovani, overview. No inhibition by 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)-N-(adamant-1-ylmethyl)thiophene-2-carboxamide, 3-(4-chlorophenyl)-4-cyano-N-(naphthalen-1-ylmethyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide, methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-N-methyl-D-methioninate, ethyl 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylate, and methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate Homo sapiens
2.5.1.58 additional information addition of a methionine residue at position 2 of 3-arylthiophenes greatly improves enzyme inhibition, antiparasitic effect of the compounds on proliferation of 4 protozoan parasites, i.e. Plasmodium falciparum, Trypanosoma brucei brucei, Trypanosoma cruzi and Leishmania donovani, overview. No inhibition by 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)-N-(adamant-1-ylmethyl)thiophene-2-carboxamide, 3-(4-chlorophenyl)-4-cyano-N-(naphthalen-1-ylmethyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide, methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-N-methyl-D-methioninate, ethyl 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylate, and methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate Trypanosoma brucei
2.5.1.58 N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonothioyl]-D-methionine
-
 Homo sapiens
2.5.1.58 N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonothioyl]-D-methionine
-
 Trypanosoma brucei
2.5.1.58 N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-D-methionine
-
 Homo sapiens
2.5.1.58 N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-D-methionine
-
 Trypanosoma brucei
2.5.1.58 N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-isoleucyl-L-methionine
-
 Homo sapiens
2.5.1.58 N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-isoleucyl-L-methionine
-
 Trypanosoma brucei
2.5.1.58 N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine
-
 Homo sapiens
2.5.1.58 N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine
-
 Trypanosoma brucei
2.5.1.58 N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-N-methyl-D-methionine
-
 Homo sapiens
2.5.1.58 N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-N-methyl-D-methionine
-
 Trypanosoma brucei
2.5.1.58 N-[[3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine
-
 Homo sapiens
2.5.1.58 N-[[3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine
-
 Trypanosoma brucei
2.5.1.58 N-[[4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine
-
 Homo sapiens
2.5.1.58 N-[[4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine
-
 Trypanosoma brucei
2.5.1.58 N-[[4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophen-2-yl]carbonyl]-L-methionine
-
 Homo sapiens
2.5.1.58 N-[[4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophen-2-yl]carbonyl]-L-methionine
-
 Trypanosoma brucei
2.5.1.58 N2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-glutamine
-
 Homo sapiens
2.5.1.58 N2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-glutamine
-
 Trypanosoma brucei
2.5.1.58 tert-butyl 2-[2-(methylsulfanyl)ethyl]hydrazinecarboxylate
-
 Homo sapiens
2.5.1.58 tert-butyl 2-[2-(methylsulfanyl)ethyl]hydrazinecarboxylate
-
 Trypanosoma brucei
2.5.1.58 [[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetic acid
-
 Homo sapiens
2.5.1.58 [[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetic acid
-
 Trypanosoma brucei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.58 (2E,6E)-farnesyl diphosphate + [protein]-L-cysteine Homo sapiens
-
 S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
-
 ?
2.5.1.58 (2E,6E)-farnesyl diphosphate + [protein]-L-cysteine Trypanosoma brucei
-
 S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.58 Homo sapiens
-
-
-
2.5.1.58 Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.58 (2E,6E)-farnesyl diphosphate + [protein]-L-cysteine
-
 Homo sapiens S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
-
 ?
2.5.1.58 (2E,6E)-farnesyl diphosphate + [protein]-L-cysteine
-
 Trypanosoma brucei S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.58 hFTase
-
 Homo sapiens
2.5.1.58 TbFTase
-
 Trypanosoma brucei

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.5.1.58 0.000042
-
 pH and temperature not specified in the publication Homo sapiens N-[[3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine
2.5.1.58 0.000042
-
 pH and temperature not specified in the publication Trypanosoma brucei N-[[3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine
2.5.1.58 0.000067
-
 pH and temperature not specified in the publication Homo sapiens N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine
2.5.1.58 0.000076
-
 pH and temperature not specified in the publication Homo sapiens N2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-glutamine
2.5.1.58 0.000077
-
 pH and temperature not specified in the publication Homo sapiens N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine
2.5.1.58 0.000079
-
 pH and temperature not specified in the publication Trypanosoma brucei N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine
2.5.1.58 0.00012
-
 pH and temperature not specified in the publication Trypanosoma brucei N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine
2.5.1.58 0.00014
-
 pH and temperature not specified in the publication Homo sapiens N-[[4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine
2.5.1.58 0.00019
-
 pH and temperature not specified in the publication Trypanosoma brucei N-[[4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methionine
2.5.1.58 0.00023
-
 pH and temperature not specified in the publication Trypanosoma brucei N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonothioyl]-D-methionine
2.5.1.58 0.00045
-
 pH and temperature not specified in the publication Homo sapiens N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-D-methionine
2.5.1.58 0.00046
-
 pH and temperature not specified in the publication Homo sapiens methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonothioyl]-D-methioninate
2.5.1.58 0.00053
-
 pH and temperature not specified in the publication Trypanosoma brucei (2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-1-[2-(methylsulfanyl)ethyl]hydrazinyl)acetic acid
2.5.1.58 0.0012
-
 pH and temperature not specified in the publication Trypanosoma brucei N2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-glutamine
2.5.1.58 0.0014
-
 pH and temperature not specified in the publication Trypanosoma brucei N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-D-methionine
2.5.1.58 0.0017
-
 pH and temperature not specified in the publication Homo sapiens N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonothioyl]-D-methionine
2.5.1.58 0.0018
-
 pH and temperature not specified in the publication Homo sapiens N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-N-methyl-D-methionine
2.5.1.58 0.0019
-
 pH and temperature not specified in the publication Homo sapiens 3-(4-chlorophenyl)-4-cyano-N'-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carbohydrazide
2.5.1.58 0.0019
-
 pH and temperature not specified in the publication Trypanosoma brucei 3-(4-chlorophenyl)-4-cyano-N'-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carbohydrazide
2.5.1.58 0.0019
-
 pH and temperature not specified in the publication Homo sapiens N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-isoleucyl-L-methionine
2.5.1.58 0.0022
-
 pH and temperature not specified in the publication Trypanosoma brucei N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-isoleucyl-L-methionine
2.5.1.58 0.0028
-
 pH and temperature not specified in the publication Trypanosoma brucei methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-D-methioninate
2.5.1.58 0.0033
-
 pH and temperature not specified in the publication Trypanosoma brucei N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-N-methyl-D-methionine
2.5.1.58 0.0036
-
 pH and temperature not specified in the publication Trypanosoma brucei methyl N-[[4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophen-2-yl]carbonyl]-L-methioninate
2.5.1.58 0.0037
-
 pH and temperature not specified in the publication Homo sapiens [[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetic acid
2.5.1.58 0.0047
-
 pH and temperature not specified in the publication Homo sapiens methyl N-[[4-cyano-3-(3,4-dihydroxyphenyl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate
2.5.1.58 0.0048
-
 pH and temperature not specified in the publication Trypanosoma brucei N-[[4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophen-2-yl]carbonyl]-L-methionine
2.5.1.58 0.0053
-
 pH and temperature not specified in the publication Trypanosoma brucei methyl N-[[4-cyano-3-(3,4-dihydroxyphenyl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate
2.5.1.58 0.0056
-
 pH and temperature not specified in the publication Homo sapiens methyl N-[[4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophen-2-yl]carbonyl]-L-methioninate
2.5.1.58 0.0082
-
 pH and temperature not specified in the publication Trypanosoma brucei methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonothioyl]-D-methioninate
2.5.1.58 0.0087
-
 pH and temperature not specified in the publication Homo sapiens N-[[4-cyano-5-(propan-2-ylsulfanyl)-3-(3,4,5-trihydroxyphenyl)thiophen-2-yl]carbonyl]-L-methionine
2.5.1.58 0.0089
-
 pH and temperature not specified in the publication Trypanosoma brucei [[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetic acid
2.5.1.58 0.0093
-
 pH and temperature not specified in the publication Homo sapiens ethyl [[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetate
2.5.1.58 0.0104
-
 pH and temperature not specified in the publication Homo sapiens (4S)-4-([[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]amino)-5-tert-butoxy-5-oxopentanoic acid
2.5.1.58 0.011
-
 pH and temperature not specified in the publication Trypanosoma brucei 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
2.5.1.58 0.016
-
 pH and temperature not specified in the publication Homo sapiens 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid
2.5.1.58 0.019
-
 pH and temperature not specified in the publication Trypanosoma brucei methyl N-[[3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate
2.5.1.58 0.02
-
 about, pH and temperature not specified in the publication Homo sapiens 5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophene-2-carboxylic acid
2.5.1.58 0.0216
-
 pH and temperature not specified in the publication Homo sapiens 3-(4-chlorophenyl)-4-cyano-N-(naphthalen-1-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide
2.5.1.58 0.022
-
 pH and temperature not specified in the publication Trypanosoma brucei ethyl [[2-([[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]amino)ethyl]sulfanyl]acetate
2.5.1.58 0.023
-
 pH and temperature not specified in the publication Homo sapiens methyl N-[[3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate
2.5.1.58 0.024
-
 pH and temperature not specified in the publication Homo sapiens 3-(4-chlorophenyl)-4-cyano-N-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide
2.5.1.58 0.024
-
 pH and temperature not specified in the publication Trypanosoma brucei 3-(4-chlorophenyl)-4-cyano-N-[2-(methylsulfanyl)ethyl]-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide
2.5.1.58 0.029
-
 pH and temperature not specified in the publication Trypanosoma brucei (4S)-4-([[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]amino)-5-tert-butoxy-5-oxopentanoic acid
2.5.1.58 0.05
-
 pH and temperature not specified in the publication Homo sapiens methyl N-[[4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate
2.5.1.58 0.05
-
 pH and temperature not specified in the publication Trypanosoma brucei methyl N-[[4-cyano-3-(dibenzo[b,d]furan-4-yl)-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-methioninate
2.5.1.58 0.05
-
 pH and temperature not specified in the publication Homo sapiens methyl N-[[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]-L-methioninate
2.5.1.58 0.05
-
 pH and temperature not specified in the publication Trypanosoma brucei methyl N-[[5-(butan-2-yl)-3-(4-chlorophenyl)-4-cyanothiophen-2-yl]carbonyl]-L-methioninate
2.5.1.58 0.05
-
 pH and temperature not specified in the publication Homo sapiens methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-isoleucyl-L-methioninate
2.5.1.58 0.05
-
 pH and temperature not specified in the publication Trypanosoma brucei methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-L-isoleucyl-L-methioninate
2.5.1.58 0.05
-
 pH and temperature not specified in the publication Homo sapiens 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)-N-adamantylthiophene-2-carboxamide
2.5.1.58 0.05
-
 pH and temperature not specified in the publication Trypanosoma brucei 3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)-N-adamantylthiophene-2-carboxamide
2.5.1.58 0.05
-
 pH and temperature not specified in the publication Trypanosoma brucei 3-(4-chlorophenyl)-4-cyano-N-(naphthalen-1-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxamide
2.5.1.58 0.05
-
 pH and temperature not specified in the publication Homo sapiens methyl N-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-D-methioninate
2.5.1.58 0.05
-
 pH and temperature not specified in the publication Homo sapiens ethyl (2-[[3-(4-chlorophenyl)-4-cyano-5-(propan-2-ylsulfanyl)thiophen-2-yl]carbonyl]-1-[2-(methylsulfanyl)ethyl]hydrazinyl)acetate