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Literature summary extracted from

  • Peng, L.; Jiang, Q.; Pan, J.; Deng, C.; Yu, J.; Wu, X.; Huang, S.; Deng, X.
    Involvement of polyphosphate kinase in virulence and stress tolerance of uropathogenic Proteus mirabilis (2016), Med. Microbiol. Immunol., 205, 97-109.
No PubMed abstract available

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.4.1 gene ppk, subcloning in Escherichia coli strain TOP10 Proteus mirabilis

Protein Variants

EC Number Protein Variants Comment Organism
2.7.4.1 additional information construction of a ppk gene encoding the PPK insertional mutant in Proteus mirabilis strain HI4320 Proteus mirabilis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.4.1 Mg2+ required Proteus mirabilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.1 ATP + (phosphate)n Proteus mirabilis
-
 ADP + (phosphate)n+1
-
 r
2.7.4.1 ATP + (phosphate)n Proteus mirabilis HI4320
-
 ADP + (phosphate)n+1
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.1 Proteus mirabilis B4EY92 gene ppk
-
2.7.4.1 Proteus mirabilis HI4320 B4EY92 gene ppk
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.1 ATP + (phosphate)n
-
 Proteus mirabilis ADP + (phosphate)n+1
-
 r
2.7.4.1 ATP + (phosphate)n
-
 Proteus mirabilis HI4320 ADP + (phosphate)n+1
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.7.4.1 PPK
-
 Proteus mirabilis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.4.1 37
-
 assay at Proteus mirabilis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.4.1 7
-
 assay at Proteus mirabilis

General Information

EC Number General Information Comment Organism
2.7.4.1 malfunction the ppk-deficient mutant is deficient in resistance to oxidative, hyperosmotic and heat stress. The swarming and biofilm formation abilities of Proteus mirabilis are also attenuated after the ppk interruption. Negative phenotypes of the ppk mutant can be restored by ppk gene complementation Proteus mirabilis
2.7.4.1 physiological function enzyme PPK is an important regulator and plays a crucial role in stress tolerance and virulence in uropathogenic Proteus mirabilis, overview. Gene ppk is required for Proteus mirabilis to invade the bladder Proteus mirabilis