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Literature summary extracted from

  • Li, H.; Guo, X.; Xu, H.; Woo, S.; Halim, V.; Morgan, C.; Wu, C.
    A role for inducible 6-phosphofructo-2-kinase in the control of neuronal glycolysis (2013), J. Nutr. Biochem., 24, 1153-1158.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.105 Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.105 ATP + beta-D-fructose 6-phosphate Mus musculus
-
ADP + beta-D-fructose 2,6-bisphosphate
-
?
2.7.1.105 ATP + beta-D-fructose 6-phosphate Mus musculus C57/BL6J
-
ADP + beta-D-fructose 2,6-bisphosphate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.105 Mus musculus A7UAK5 gene PFKFB3, isozyme iPFK2 is inducible
-
2.7.1.105 Mus musculus C57/BL6J A7UAK5 gene PFKFB3, isozyme iPFK2 is inducible
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.105 brain
-
Mus musculus
-
2.7.1.105 hypothalamus
-
Mus musculus
-
2.7.1.105 N-43/5 cell
-
Mus musculus
-
2.7.1.105 neuron isozyme iPFK2 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.105 ATP + beta-D-fructose 6-phosphate
-
Mus musculus ADP + beta-D-fructose 2,6-bisphosphate
-
?
2.7.1.105 ATP + beta-D-fructose 6-phosphate
-
Mus musculus C57/BL6J ADP + beta-D-fructose 2,6-bisphosphate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.105 6-phosphofructo-2-kinase
-
Mus musculus
2.7.1.105 iPFK2
-
Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.105 ATP
-
Mus musculus

Expression

EC Number Organism Comment Expression
2.7.1.105 Mus musculus re-feeding increases plasma levels of glucose and insulin and stimulates PFKFB3 expression. Glucose and insulin stimulate PFKFB3 expression, increase glycolysis, and decrease AMPK phosphorylation in clonal hypothalamic neurons up

General Information

EC Number General Information Comment Organism
2.7.1.105 malfunction knockdown of PFKFB3/iPFK2 in N-43/5 neurons causes a decrease in rates of glycolysis, which is accompanied by increased AMPK phosphorylation, increased AgRP mRNA levels and decreased CART mRNA levels. Overexpression of PFKFB3/iPFK2 in N-43/5 neurons causes an increase in glycolysis, which is accompanied by decreased AMPK phosphorylation and decreased AgRP mRNA levels and increased CART mRNA levels Mus musculus
2.7.1.105 metabolism re-feeding increases plasma levels of glucose and insulin and stimulates PFKFB3 expression. Glucose and insulin stimulate PFKFB3 expression, increase glycolysis, and decrease AMPK phosphorylation in clonal hypothalamic neurons Mus musculus
2.7.1.105 physiological function role for PFKFB3/iPFK2 in regulating glycolysis in hypothalamic neurons, in the context of neuronal glucose sensing and neuropeptide expression. PFKFB3/iPFK2 responds to re-feeding, which in turn stimulates hypothalamic glycolysis and decreases hypothalamic AMPK phosphorylation and alters neuropeptide expression in a pattern that is associated with suppression of food intake Mus musculus