EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.59 | GGTi-2147 | a potent and selective inhibitor of GGT; potent and selective inhibitor of GGT | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.5.1.59 | additional information | the spatiotemporal expression pattern of GGT is correlated with the synaptogenesis in vivo | Rattus norvegicus | - |
- |
2.5.1.59 | synapse | GGTalpha and GGTbeta are enriched in synaptosome and postsynaptic density fractions from P14 hippocampus | Rattus norvegicus | 45202 | - |
2.5.1.59 | synaptosome | GGTalpha and GGTbeta are enriched in synaptosome and postsynaptic density fractions from P14 hippocampus | Rattus norvegicus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.59 | geranylgeranyl diphosphate + Cdc42-cysteine | Rattus norvegicus | - |
S-geranylgeranyl-Cdc42 + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + Cdc42-cysteine | Rattus norvegicus Sprague-Dawley | - |
S-geranylgeranyl-Cdc42 + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + protein-cysteine | Rattus norvegicus | - |
S-geranylgeranyl-protein + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + protein-cysteine | Rattus norvegicus Sprague-Dawley | - |
S-geranylgeranyl-protein + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + Rac-cysteine | Rattus norvegicus | - |
S-geranylgeranyl-Rac + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + Rac-cysteine | Rattus norvegicus Sprague-Dawley | - |
S-geranylgeranyl-Rac + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + Rap1A-cysteine | Rattus norvegicus | - |
S-geranylgeranyl-Rap1A + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + Rap1A-cysteine | Rattus norvegicus Sprague-Dawley | - |
S-geranylgeranyl-Rap1A + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + Rho GTPase-cysteine | Rattus norvegicus | - |
S-geranylgeranyl-Rho GTPase + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + Rho GTPase-cysteine | Rattus norvegicus Sprague-Dawley | - |
S-geranylgeranyl-Rho GTPase + diphosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.59 | Rattus norvegicus | P53610 | subunit beta | - |
2.5.1.59 | Rattus norvegicus | Q04631 | subunit alpha | - |
2.5.1.59 | Rattus norvegicus Sprague-Dawley | P53610 | subunit beta | - |
2.5.1.59 | Rattus norvegicus Sprague-Dawley | Q04631 | subunit alpha | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.5.1.59 | brain | - |
Rattus norvegicus | - |
2.5.1.59 | central nervous system | - |
Rattus norvegicus | - |
2.5.1.59 | hippocampus | - |
Rattus norvegicus | - |
2.5.1.59 | neuron | hippocampal and cortical | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.59 | geranylgeranyl diphosphate + Cdc42-cysteine | - |
Rattus norvegicus | S-geranylgeranyl-Cdc42 + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + Cdc42-cysteine | - |
Rattus norvegicus Sprague-Dawley | S-geranylgeranyl-Cdc42 + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + protein-cysteine | - |
Rattus norvegicus | S-geranylgeranyl-protein + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + protein-cysteine | - |
Rattus norvegicus Sprague-Dawley | S-geranylgeranyl-protein + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + Rac-cysteine | - |
Rattus norvegicus | S-geranylgeranyl-Rac + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + Rac-cysteine | - |
Rattus norvegicus Sprague-Dawley | S-geranylgeranyl-Rac + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + Rap1A-cysteine | - |
Rattus norvegicus | S-geranylgeranyl-Rap1A + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + Rap1A-cysteine | - |
Rattus norvegicus Sprague-Dawley | S-geranylgeranyl-Rap1A + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + Rho GTPase-cysteine | - |
Rattus norvegicus | S-geranylgeranyl-Rho GTPase + diphosphate | - |
? | |
2.5.1.59 | geranylgeranyl diphosphate + Rho GTPase-cysteine | - |
Rattus norvegicus Sprague-Dawley | S-geranylgeranyl-Rho GTPase + diphosphate | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.5.1.59 | dimer | the enzyme includes two subunits: an alpha subunit (GGTalpha), the catalytic subunit, that is shared with farnesyltransferase, EC 2.5.1.58, and a distinct beta subunit (GGTbeta), which is responsible for substrate binding | Rattus norvegicus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.5.1.59 | geranylgeranyltransferase I | - |
Rattus norvegicus |
2.5.1.59 | GGT | - |
Rattus norvegicus |
2.5.1.59 | GGTalpha | - |
Rattus norvegicus |
2.5.1.59 | GGTbeta | - |
Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.5.1.59 | 7.5 | - |
assay at | Rattus norvegicus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.5.1.59 | malfunction | downregulation or inhibition of GGT decreases synaptogenesis | Rattus norvegicus |
2.5.1.59 | malfunction | overexpression of GGTbeta promotes the linear density of post-synaptic density protein 95 (PSD 95) and synapsin 1, two major molecular markers of synaptogenesis, while downregulation or inhibition of GGT decreases synaptogenesis | Rattus norvegicus |
2.5.1.59 | additional information | the enzyme includes two subunits: an alpha subunit (GGTalpha), the catalytic subunit, that is shared with farnesyltransferase, EC 2.5.1.58, and a distinct beta subunit (GGTbeta), which is responsible for substrate binding | Rattus norvegicus |
2.5.1.59 | physiological function | the enzyme mediates lipid modification of Rho small GTPases, such as Rho, Rac, and Cdc42, which are important for neuronal synaptogenesis. It promotes the basal and neuronal activity and brain-derived neurotrophic factor (BDNF)-induced dendritic morphogenesis of cultured hippocampal neurons and cerebellar slices. Function and mechanism of geranylgeranyltransferase I in neuronal synaptogenesis, enzyme regulation by factors that promote synaptogenesis, overview. The activities of GGT and Rac are regulated by BDNF | Rattus norvegicus |