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Literature summary extracted from

  • Garriga, D.; Ferrer-Orta, C.; Querol-Audi, J.; Oliva, B.; Verdaguer, N.
    Role of motif B loop in allosteric regulation of RNA-dependent RNA polymerization activity (2013), J. Mol. Biol., 425, 2279-2287.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.7.48 additional information the HCV replication reaction in vitro is stimulated by the protein NS5A in a template-specific manner Hepacivirus C
2.7.7.48 additional information the HCV replication reaction in vitro is stimulated by the protein NS5A in a template-specific manner Infectious bursal disease virus
2.7.7.48 additional information the HCV replication reaction in vitro is stimulated by the protein NS5A in a template-specific manner Enterovirus A71
2.7.7.48 additional information the HCV replication reaction in vitro is stimulated by the protein NS5A in a template-specific manner infectious pancreatic necrosis virus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn Foot-and-mouth disease virus
-
 diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn Hepacivirus C
-
 diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn Infectious bursal disease virus
-
 diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn Norwalk virus
-
 diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn Enterovirus A71
-
 diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn infectious pancreatic necrosis virus
-
 diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn Foot-and-mouth disease virus C-S8c1
-
 diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn Infectious bursal disease virus VP1
-
 diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn Hepacivirus C NS5B
-
 diphosphate + RNAn+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 Enterovirus A71
-
-
-
2.7.7.48 Foot-and-mouth disease virus
-
-
-
2.7.7.48 Foot-and-mouth disease virus C-S8c1
-
-
-
2.7.7.48 Hepacivirus C
-
 strains jfh1 and j6, genotype 2a HCV
-
2.7.7.48 Hepacivirus C NS5B
-
 strains jfh1 and j6, genotype 2a HCV
-
2.7.7.48 Infectious bursal disease virus
-
-
-
2.7.7.48 Infectious bursal disease virus VP1
-
-
-
2.7.7.48 infectious pancreatic necrosis virus P22173 a birnavirus
-
2.7.7.48 Norwalk virus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn
-
 Foot-and-mouth disease virus diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn
-
 Hepacivirus C diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn
-
 Infectious bursal disease virus diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn
-
 Norwalk virus diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn
-
 Enterovirus A71 diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn
-
 infectious pancreatic necrosis virus diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn rNTP substrate binding structure, multistep model of nucleotide incorporation, overview Foot-and-mouth disease virus diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn rNTP substrate binding structure, multistep model of nucleotide incorporation, overview Hepacivirus C diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn rNTP substrate binding structure, multistep model of nucleotide incorporation, overview Infectious bursal disease virus diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn rNTP substrate binding structure, multistep model of nucleotide incorporation, overview Norwalk virus diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn rNTP substrate binding structure, multistep model of nucleotide incorporation, overview Enterovirus A71 diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn rNTP substrate binding structure, multistep model of nucleotide incorporation, overview infectious pancreatic necrosis virus diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn
-
 Foot-and-mouth disease virus C-S8c1 diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn rNTP substrate binding structure, multistep model of nucleotide incorporation, overview Foot-and-mouth disease virus C-S8c1 diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn
-
 Infectious bursal disease virus VP1 diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn rNTP substrate binding structure, multistep model of nucleotide incorporation, overview Infectious bursal disease virus VP1 diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn
-
 Hepacivirus C NS5B diphosphate + RNAn+1
-
 ?
2.7.7.48 nucleoside triphosphate + RNAn rNTP substrate binding structure, multistep model of nucleotide incorporation, overview Hepacivirus C NS5B diphosphate + RNAn+1
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.7.48 More enzyme domain structure, structure-function relationship, overview Foot-and-mouth disease virus
2.7.7.48 More enzyme domain structure, structure-function relationship, overview Norwalk virus
2.7.7.48 More open and closed enzyme conformation, and enzyme domain structure, structure-function relationship, overview Hepacivirus C
2.7.7.48 More open and closed enzyme conformation, and enzyme domain structure, structure-function relationship, overview Infectious bursal disease virus
2.7.7.48 More open and closed enzyme conformation, and enzyme domain structure, structure-function relationship, overview Enterovirus A71
2.7.7.48 More open and closed enzyme conformation, and enzyme domain structure, structure-function relationship, overview infectious pancreatic necrosis virus

Synonyms

EC Number Synonyms Comment Organism
2.7.7.48 NS5B polymerase
-
 Hepacivirus C
2.7.7.48 RDRP
-
 Foot-and-mouth disease virus
2.7.7.48 RDRP
-
 Hepacivirus C
2.7.7.48 RDRP
-
 Infectious bursal disease virus
2.7.7.48 RDRP
-
 Norwalk virus
2.7.7.48 RDRP
-
 Enterovirus A71
2.7.7.48 RDRP
-
 infectious pancreatic necrosis virus

General Information

EC Number General Information Comment Organism
2.7.7.48 additional information overall enzyme structure analysis from crystal structure, PDB ID 1WNE. Structure solution of RdRP-RNA-rNTP complexes, overview Foot-and-mouth disease virus
2.7.7.48 additional information overall enzyme structure analysis from crystal structure, PDB ID 3ZED. Structure solution of RdRP-RNA-rNTP complexes, open and closed conformations of the B-loop in IBDV VP, overview infectious pancreatic necrosis virus
2.7.7.48 additional information overall enzyme structure analysis from crystal structure, PDB IDs 2PUS and 2R70. Structure solution of RdRP-RNA-rNTP complexes, conformational changes in the B-loop of RdRP, overview Infectious bursal disease virus
2.7.7.48 additional information overall enzyme structure analysis from crystal structure, PDB IDs 2XXD and 4E76. Structure solution of RdRP-RNA-rNTP complexes, overview Hepacivirus C
2.7.7.48 additional information overall enzyme structure analysis from crystal structure, PDB IDs 3N6L, 3N6N, and 3N6M, conformational changes in the B-loop of RdRP. Structure solution of RdRP-RNA-rNTP complexes, overview Enterovirus A71
2.7.7.48 additional information overall enzyme structure analysis from crystal structures, PDB IDs 1SH0, 3BSO, and 1SH3. Structure solution of RdRP-RNA-rNTP complexes, conformational changes in the B-loop of RdRP, overview Norwalk virus
2.7.7.48 physiological function role of motif B loop in allosteric regulation of RNA-dependent RNA polymerization activity, allosteric factors regulating B-loop dynamics Foot-and-mouth disease virus
2.7.7.48 physiological function role of motif B loop in allosteric regulation of RNA-dependent RNA polymerization activity, allosteric factors regulating B-loop dynamics Hepacivirus C
2.7.7.48 physiological function role of motif B loop in allosteric regulation of RNA-dependent RNA polymerization activity, allosteric factors regulating B-loop dynamics Infectious bursal disease virus
2.7.7.48 physiological function role of motif B loop in allosteric regulation of RNA-dependent RNA polymerization activity, allosteric factors regulating B-loop dynamics Norwalk virus
2.7.7.48 physiological function role of motif B loop in allosteric regulation of RNA-dependent RNA polymerization activity, allosteric factors regulating B-loop dynamics Enterovirus A71
2.7.7.48 physiological function role of motif B loop in allosteric regulation of RNA-dependent RNA polymerization activity, allosteric factors regulating B-loop dynamics infectious pancreatic necrosis virus