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Literature summary extracted from

  • Papp, E.; Balogun, K.; Banko, N.; Mohammadi, H.; Loutfy, M.; Yudin, M.; Shah, R.; Macgillivray, J.; Murphy, K.; Walmsley, S.; Silverman, M.; Serghides, L.
    Low prolactin and high 20-alpha-hydroxysteroid dehydrogenase levels contribute to lower progesterone levels in hiv-infected pregnant women exposed to protease inhibitor-based combination antiretroviral therapy (2016), J. Infect. Dis., 213, 1532-1540.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.149 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.149 placenta
-
 Homo sapiens
-
1.1.1.149 trophoblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.149 progesterone + NADH + H+
-
 Homo sapiens 20alpha-hydroxyprogesterone + NAD+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.149 20-alpha-hydroxysteroid dehydrogenase
-
 Homo sapiens
1.1.1.149 20alpha-HSD
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.149 NADH
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
1.1.1.149 Homo sapiens human immunodeficiency virus-infected pregnant women receiving protease inhibitor-based combination antiretroviral therapy show an elevation in placental expression of the 20-alpha-hydroxysteroid dehydrogenase up
1.1.1.149 Homo sapiens placental enzyme expression is significantly elevated in human immunodeficiency virus-infected pregnant women exposed to protease inhibitor-based combination antiretroviral therapy up