BRENDA - Enzyme Database show

Non-viral deoxyribonucleoside kinases - diversity and practical use

Slot Christiansen, L.; Munch-Petersen, B.; Knecht, W.; J. Genet. Genomics 42, 235-248 (2015)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
2.7.1.145
medicine
suicide gene dmdnk in several cancer cell lines, overview. In vivo testing in a xenograft model for breast cancer, both wild-type DmdNK and mutants of DmdNK are combined with gemcitabine (dFdC, 2',2'-difluoro-deoxycytidine) as the NA prodrug and a positive effect of decreasing tumor volume and increased survival time
Drosophila melanogaster
2.7.1.145
additional information
DmdNK broad substrate specificity and fast turnover rate make it an interesting candidate for suicide gene therapy, as well as in numerous biotechnological applications
Drosophila melanogaster
Crystallization (Commentary)
EC Number
Crystallization
Organism
2.7.1.145
crystal structure determination, PDB IDs 1OE0, 1OT3, 1J90, 1ZM7, 1ZMX, 2JCS, 2VP0, 2VP2, 2VP4, 2VP, 2VP6, 2VP9, 2VPP, 2VQ, and 2JJ8
Drosophila melanogaster
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.1.145
cytosol
-
Bombyx mori
5829
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.1.145
Mg2+
required
Anopheles gambiae
2.7.1.145
Mg2+
required
Bombyx mori
2.7.1.145
Mg2+
required
Drosophila melanogaster
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.145
ATP + 2'-deoxyadenosine
Anopheles gambiae
-
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxyadenosine
Drosophila melanogaster
-
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxyadenosine
Bombyx mori
-
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxycytidine
Anopheles gambiae
-
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxycytidine
Drosophila melanogaster
-
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxycytidine
Bombyx mori
-
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxyguanosine
Anopheles gambiae
-
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxyguanosine
Drosophila melanogaster
-
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxyguanosine
Bombyx mori
-
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxyribonucleoside
Anopheles gambiae
-
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxyribonucleoside
Drosophila melanogaster
-
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxyribonucleoside
Bombyx mori
-
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxythymidine
Anopheles gambiae
-
ADP + 2'-deoxythymidine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxythymidine
Drosophila melanogaster
-
ADP + 2'-deoxythymidine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxythymidine
Bombyx mori
-
ADP + 2'-deoxythymidine 5'-phosphate
-
-
?
2.7.1.145
additional information
Bombyx mori
the multisubstrate kinase from Bombyx mori (BmdNK) prefers pyrimidines
?
-
-
-
2.7.1.145
additional information
Drosophila melanogaster
the multisubstrate kinase from Drosophila prefers pyrimidines
?
-
-
-
2.7.1.145
additional information
Anopheles gambiae
the multisubstrate kinase from from Anopheles gambiae (AgdNK) prefers purines
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.7.1.145
Anopheles gambiae
Q86LB8
gene dnk
-
2.7.1.145
Bombyx mori
Q9BKL3
gene dnk
-
2.7.1.145
Drosophila melanogaster
Q9XZT6
gene dnk
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.145
ATP + 2'-deoxyadenosine
-
738781
Anopheles gambiae
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyadenosine
-
738781
Drosophila melanogaster
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyadenosine
-
738781
Bombyx mori
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyadenosine
1% of the activity with 2'-deoxythymidine
738781
Drosophila melanogaster
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyadenosine
2.7% of the activity with 2'-deoxycytidine
738781
Bombyx mori
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyadenosine
48% of the activity with 2'-deoxythymidine
738781
Anopheles gambiae
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxycytidine
-
738781
Anopheles gambiae
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxycytidine
-
738781
Drosophila melanogaster
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxycytidine
-
738781
Bombyx mori
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxycytidine
best substrate
738781
Bombyx mori
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxycytidine
88% of the activity with 2'-deoxythymidine
738781
Drosophila melanogaster
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxycytidine
99% of the activity with 2'-deoxythymidine
738781
Anopheles gambiae
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyguanosine
-
738781
Anopheles gambiae
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyguanosine
-
738781
Drosophila melanogaster
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyguanosine
-
738781
Bombyx mori
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyguanosine
0.2% of the activity with 2'-deoxythymidine
738781
Drosophila melanogaster
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyguanosine
0.5% of the activity with 2'-deoxycytidine
738781
Bombyx mori
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyguanosine
83% of the activity with 2'-deoxythymidine
738781
Anopheles gambiae
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyribonucleoside
-
738781
Anopheles gambiae
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyribonucleoside
-
738781
Drosophila melanogaster
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyribonucleoside
-
738781
Bombyx mori
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxythymidine
-
738781
Anopheles gambiae
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxythymidine
-
738781
Drosophila melanogaster
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxythymidine
-
738781
Bombyx mori
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxythymidine
best substrate
738781
Anopheles gambiae
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxythymidine
best substrate
738781
Drosophila melanogaster
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxythymidine
65% of the activity with 2'-deoxycytidine
738781
Bombyx mori
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
2.7.1.145
additional information
the multisubstrate kinase from Bombyx mori (BmdNK) prefers pyrimidines
738781
Bombyx mori
?
-
-
-
-
2.7.1.145
additional information
the multisubstrate kinase from Drosophila prefers pyrimidines
738781
Drosophila melanogaster
?
-
-
-
-
2.7.1.145
additional information
the multisubstrate kinase from from Anopheles gambiae (AgdNK) prefers purines
738781
Anopheles gambiae
?
-
-
-
-
2.7.1.145
additional information
substrate binding of non-TK1-like dNKs, overview
738781
Anopheles gambiae
?
-
-
-
-
2.7.1.145
additional information
substrate binding of non-TK1-like dNKs, overview
738781
Drosophila melanogaster
?
-
-
-
-
2.7.1.145
additional information
substrate binding of non-TK1-like dNKs, overview
738781
Bombyx mori
?
-
-
-
-
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.145
ATP
-
Anopheles gambiae
2.7.1.145
ATP
-
Bombyx mori
2.7.1.145
ATP
-
Drosophila melanogaster
Application (protein specific)
EC Number
Application
Commentary
Organism
2.7.1.145
medicine
suicide gene dmdnk in several cancer cell lines, overview. In vivo testing in a xenograft model for breast cancer, both wild-type DmdNK and mutants of DmdNK are combined with gemcitabine (dFdC, 2',2'-difluoro-deoxycytidine) as the NA prodrug and a positive effect of decreasing tumor volume and increased survival time
Drosophila melanogaster
2.7.1.145
additional information
DmdNK broad substrate specificity and fast turnover rate make it an interesting candidate for suicide gene therapy, as well as in numerous biotechnological applications
Drosophila melanogaster
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.7.1.145
ATP
-
Anopheles gambiae
2.7.1.145
ATP
-
Bombyx mori
2.7.1.145
ATP
-
Drosophila melanogaster
Crystallization (Commentary) (protein specific)
EC Number
Crystallization
Organism
2.7.1.145
crystal structure determination, PDB IDs 1OE0, 1OT3, 1J90, 1ZM7, 1ZMX, 2JCS, 2VP0, 2VP2, 2VP4, 2VP, 2VP6, 2VP9, 2VPP, 2VQ, and 2JJ8
Drosophila melanogaster
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.7.1.145
cytosol
-
Bombyx mori
5829
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.7.1.145
Mg2+
required
Anopheles gambiae
2.7.1.145
Mg2+
required
Bombyx mori
2.7.1.145
Mg2+
required
Drosophila melanogaster
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.7.1.145
ATP + 2'-deoxyadenosine
Anopheles gambiae
-
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxyadenosine
Drosophila melanogaster
-
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxyadenosine
Bombyx mori
-
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxycytidine
Anopheles gambiae
-
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxycytidine
Drosophila melanogaster
-
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxycytidine
Bombyx mori
-
ADP + 2'-deoxycytidine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxyguanosine
Anopheles gambiae
-
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxyguanosine
Drosophila melanogaster
-
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxyguanosine
Bombyx mori
-
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxyribonucleoside
Anopheles gambiae
-
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxyribonucleoside
Drosophila melanogaster
-
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxyribonucleoside
Bombyx mori
-
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxythymidine
Anopheles gambiae
-
ADP + 2'-deoxythymidine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxythymidine
Drosophila melanogaster
-
ADP + 2'-deoxythymidine 5'-phosphate
-
-
?
2.7.1.145
ATP + 2'-deoxythymidine
Bombyx mori
-
ADP + 2'-deoxythymidine 5'-phosphate
-
-
?
2.7.1.145
additional information
Bombyx mori
the multisubstrate kinase from Bombyx mori (BmdNK) prefers pyrimidines
?
-
-
-
2.7.1.145
additional information
Drosophila melanogaster
the multisubstrate kinase from Drosophila prefers pyrimidines
?
-
-
-
2.7.1.145
additional information
Anopheles gambiae
the multisubstrate kinase from from Anopheles gambiae (AgdNK) prefers purines
?
-
-
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.7.1.145
ATP + 2'-deoxyadenosine
-
738781
Anopheles gambiae
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyadenosine
-
738781
Drosophila melanogaster
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyadenosine
-
738781
Bombyx mori
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyadenosine
1% of the activity with 2'-deoxythymidine
738781
Drosophila melanogaster
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyadenosine
2.7% of the activity with 2'-deoxycytidine
738781
Bombyx mori
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyadenosine
48% of the activity with 2'-deoxythymidine
738781
Anopheles gambiae
ADP + 2'-deoxyadenosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxycytidine
-
738781
Anopheles gambiae
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxycytidine
-
738781
Drosophila melanogaster
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxycytidine
-
738781
Bombyx mori
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxycytidine
best substrate
738781
Bombyx mori
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxycytidine
88% of the activity with 2'-deoxythymidine
738781
Drosophila melanogaster
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxycytidine
99% of the activity with 2'-deoxythymidine
738781
Anopheles gambiae
ADP + 2'-deoxycytidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyguanosine
-
738781
Anopheles gambiae
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyguanosine
-
738781
Drosophila melanogaster
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyguanosine
-
738781
Bombyx mori
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyguanosine
0.2% of the activity with 2'-deoxythymidine
738781
Drosophila melanogaster
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyguanosine
0.5% of the activity with 2'-deoxycytidine
738781
Bombyx mori
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyguanosine
83% of the activity with 2'-deoxythymidine
738781
Anopheles gambiae
ADP + 2'-deoxyguanosine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyribonucleoside
-
738781
Anopheles gambiae
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyribonucleoside
-
738781
Drosophila melanogaster
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxyribonucleoside
-
738781
Bombyx mori
ADP + 2'-deoxyribonucleoside 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxythymidine
-
738781
Anopheles gambiae
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxythymidine
-
738781
Drosophila melanogaster
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxythymidine
-
738781
Bombyx mori
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxythymidine
best substrate
738781
Anopheles gambiae
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxythymidine
best substrate
738781
Drosophila melanogaster
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
2.7.1.145
ATP + 2'-deoxythymidine
65% of the activity with 2'-deoxycytidine
738781
Bombyx mori
ADP + 2'-deoxythymidine 5'-phosphate
-
-
-
?
2.7.1.145
additional information
the multisubstrate kinase from Bombyx mori (BmdNK) prefers pyrimidines
738781
Bombyx mori
?
-
-
-
-
2.7.1.145
additional information
the multisubstrate kinase from Drosophila prefers pyrimidines
738781
Drosophila melanogaster
?
-
-
-
-
2.7.1.145
additional information
the multisubstrate kinase from from Anopheles gambiae (AgdNK) prefers purines
738781
Anopheles gambiae
?
-
-
-
-
2.7.1.145
additional information
substrate binding of non-TK1-like dNKs, overview
738781
Anopheles gambiae
?
-
-
-
-
2.7.1.145
additional information
substrate binding of non-TK1-like dNKs, overview
738781
Drosophila melanogaster
?
-
-
-
-
2.7.1.145
additional information
substrate binding of non-TK1-like dNKs, overview
738781
Bombyx mori
?
-
-
-
-
General Information
EC Number
General Information
Commentary
Organism
2.7.1.145
evolution
evolution of dNKs, overview. The two families of dNKs, the TK1-like kinases and the non-TK1-like kinases, have overall unique monomer structures and only share significant protein sequence similarity at the Ploop, a glycine rich ATP binding domain close to the N-terminus. This suggests that the two families have different evolutionary origins. The insect dNK is a non-TK1 like kinase
Anopheles gambiae
2.7.1.145
evolution
evolution of dNKs, overview. The two families of dNKs, the TK1-like kinases and the non-TK1-like kinases, have overall unique monomer structures and only share significant protein sequence similarity at the Ploop, a glycine rich ATP binding domain close to the N-terminus. This suggests that the two families have different evolutionary origins. The insect dNK is a non-TK1 like kinase
Bombyx mori
2.7.1.145
evolution
evolution of dNKs, overview. The two families of dNKs, the TK1-like kinases and the non-TK1-like kinases, have overall unique monomer structures and only share significant protein sequence similarity at the Ploop, a glycine rich ATP binding domain close to the N-terminus. This suggests that the two families have different evolutionary origins. The insect dNK is a non-TK1 like kinase
Drosophila melanogaster
2.7.1.145
additional information
structure of non-TK1 like kinases, overview
Anopheles gambiae
2.7.1.145
additional information
structure of non-TK1 like kinases, overview
Bombyx mori
2.7.1.145
additional information
structure of non-TK1 like kinases, overview
Drosophila melanogaster
2.7.1.145
physiological function
DmdNK is cell cycle regulated and under the control of cyclin E and the dE2F1 transcription factor, involved in G1/S phase transition
Drosophila melanogaster
General Information (protein specific)
EC Number
General Information
Commentary
Organism
2.7.1.145
evolution
evolution of dNKs, overview. The two families of dNKs, the TK1-like kinases and the non-TK1-like kinases, have overall unique monomer structures and only share significant protein sequence similarity at the Ploop, a glycine rich ATP binding domain close to the N-terminus. This suggests that the two families have different evolutionary origins. The insect dNK is a non-TK1 like kinase
Anopheles gambiae
2.7.1.145
evolution
evolution of dNKs, overview. The two families of dNKs, the TK1-like kinases and the non-TK1-like kinases, have overall unique monomer structures and only share significant protein sequence similarity at the Ploop, a glycine rich ATP binding domain close to the N-terminus. This suggests that the two families have different evolutionary origins. The insect dNK is a non-TK1 like kinase
Bombyx mori
2.7.1.145
evolution
evolution of dNKs, overview. The two families of dNKs, the TK1-like kinases and the non-TK1-like kinases, have overall unique monomer structures and only share significant protein sequence similarity at the Ploop, a glycine rich ATP binding domain close to the N-terminus. This suggests that the two families have different evolutionary origins. The insect dNK is a non-TK1 like kinase
Drosophila melanogaster
2.7.1.145
additional information
structure of non-TK1 like kinases, overview
Anopheles gambiae
2.7.1.145
additional information
structure of non-TK1 like kinases, overview
Bombyx mori
2.7.1.145
additional information
structure of non-TK1 like kinases, overview
Drosophila melanogaster
2.7.1.145
physiological function
DmdNK is cell cycle regulated and under the control of cyclin E and the dE2F1 transcription factor, involved in G1/S phase transition
Drosophila melanogaster