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Literature summary extracted from

  • Montresor, A.; Bolomini-Vittori, M.; Toffali, L.; Rossi, B.; Constantin, G.; Laudanna, C.
    JAK tyrosine kinases promote hierarchical activation of Rho and Rap modules of integrin activation (2013), J. Cell Biol., 203, 1003-1019.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.2 CXCL12
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.10.2 120000
-
 x * 120000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.10.2 ? x * 120000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 JAK2
-
 Homo sapiens
2.7.10.2 Jak3
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.10.2 physiological function JAK tyrosine kinases control integrin activation and dependent lymphocyte trafficking by bridging chemokine receptors to the concurrent and hierarchical activation of the Rho and Rap modules of integrin activation Homo sapiens