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Literature summary extracted from

  • Booij, T.; Klop, M.; Yan, K.; Szantai-Kis, C.; Szokol, B.; Orfi, L.; Van De Water, B.; Keri, G.; Price, L.
    Development of a 3D tissue culture-based high-content screening platform that uses phenotypic profiling to discriminate selective inhibitors of receptor tyrosine kinases (2016), J. Biomol. Screen., 21, 912-922.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.1 afatinib
-
 Homo sapiens
2.7.10.1 AG1478
-
 Homo sapiens
2.7.10.1 cabozantinib
-
 Homo sapiens
2.7.10.1 cetuximab
-
 Homo sapiens
2.7.10.1 dacomitinib
-
 Homo sapiens
2.7.10.1 erlotinib
-
 Homo sapiens
2.7.10.1 foretinib
-
 Homo sapiens
2.7.10.1 gefitinib
-
 Homo sapiens
2.7.10.1 Genentech 5D5Fab
-
 Homo sapiens
2.7.10.1 lapatinib
-
 Homo sapiens
2.7.10.1 PHA-665752
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.1 ATP + a [protein]-L-tyrosine Homo sapiens
-
 ADP + a [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.1 PC-3 cell
-
 Homo sapiens
-
2.7.10.1 prostate adenocarcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.1 ATP + a [protein]-L-tyrosine
-
 Homo sapiens ADP + a [protein]-L-tyrosine phosphate
-
 ?
2.7.10.1 ATP + poly-Ala-Glu-Lys-Tyr substrate used for c-Met Homo sapiens ADP * poly-Ala-L-Glu-L-Lys-L-tyrosine phosphate
-
 ?
2.7.10.1 ATP + poly-Glu-Tyr substrate used for EGFR Homo sapiens ADP + poly-L-Glu-L-tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.1 c-met
-
 Homo sapiens
2.7.10.1 Egfr
-
 Homo sapiens