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Literature summary extracted from
- The reaction mechanism of methyl-coenzyme M reductase: how an enzyme enforces strict binding order (2015), J. Biol. Chem., 290, 9322-9334.
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.8.4.1 | 0.169 | - |
CoB | at pH 7.6 and 25°C | Methanothermobacter marburgensis |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 2.8.4.1 | 270000 | - |
gel filtration | Methanothermobacter marburgensis |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.8.4.1 | methyl-CoM + CoB | Methanothermobacter marburgensis | - |
CoM-S-S-CoB + methane | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.8.4.1 | Methanothermobacter marburgensis | - |
formerly Methanothermobacter thermoautotrophicum strain Marburg | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.8.4.1 | methyl-CoM + CoB | - |
Methanothermobacter marburgensis | CoM-S-S-CoB + methane | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 2.8.4.1 | dimer of heterotrimers | - |
Methanothermobacter marburgensis |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.8.4.1 | MCR | - |
Methanothermobacter marburgensis |
| 2.8.4.1 | methyl-coenzyme M reductase | - |
Methanothermobacter marburgensis |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.8.4.1 | 18 | - |
CoB | at pH 7.6 and 25°C | Methanothermobacter marburgensis | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.8.4.1 | coenzyme F430 | - |
Methanothermobacter marburgensis | |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 2.8.4.1 | metabolism | the enzyme catalyzes the final step in methanogenesis | Methanothermobacter marburgensis |
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Release 2023.1 (January 2023)
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