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Literature summary extracted from

  • Weiser, B.P.; Eckenhoff, R.G.
    Propofol inhibits SIRT2 deacetylase through a conformation-specific, allosteric site (2015), J. Biol. Chem., 290, 8559-8568.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.286 (7aS,12aS)-7-(4-chlorophenyl)-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinoline about 5% inhibition at 0.05 mM Rattus norvegicus
2.3.1.286 (7aS,12aS)-7-(4-methoxyphenyl)-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinoline about 38% inhibition at 0.05 mM Rattus norvegicus
2.3.1.286 (7aS,12aS)-7-phenyl-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinoline about 18% inhibition at 0.05 mM Rattus norvegicus
2.3.1.286 (7aS,12aS)-7-[4-(thiophen-2-yl)phenyl]-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinoline about 16% inhibition at 0.05 mM Rattus norvegicus
2.3.1.286 (7aS,12aS)-9-bromo-7-(4-chlorophenyl)-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinoline about 50% inhibition at 0.05 mM Rattus norvegicus
2.3.1.286 (7aS,12aS)-9-bromo-7-(4-fluorophenyl)-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinoline about 65% inhibition at 0.05 mM Rattus norvegicus
2.3.1.286 (7aS,12aS)-9-bromo-7-(4-methoxyphenyl)-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinoline about 65% inhibition at 0.05 mM Rattus norvegicus
2.3.1.286 (7aS,12aS)-9-bromo-7-phenyl-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinoline about 70% inhibition at 0.05 mM Rattus norvegicus
2.3.1.286 (7aS,12aS)-9-bromo-7-[4-(furan-2-yl)phenyl]-1,6,7,7a,12,12a-hexahydroindolo[3,2-c]pyrazolo[3,4-f]quinoline about 78% inhibition at 0.05 mM Rattus norvegicus
2.3.1.286 meta-azi-propofol only binds specifically and competitively to the enzyme when co-equilibrated with other substrates Homo sapiens
2.3.1.286 meta-azi-propofol only binds specifically and competitively to the enzyme when co-equilibrated with other substrates Rattus norvegicus
2.3.1.286 propofol only binds specifically and competitively to the enzyme when co-equilibrated with other substrates Homo sapiens
2.3.1.286 propofol only binds specifically and competitively to the enzyme when co-equilibrated with other substrates Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.286 37000
-
 x * 37000, SDS-PAGE Rattus norvegicus
2.3.1.286 37000
-
 x * 37000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.286 NAD+ + [alpha-tubulin]-N6-acyl-L-lysine Rattus norvegicus
-
 nicotinamide + [alpha-tubulin]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + [alpha-tubulin]-N6-acyl-L-lysine Homo sapiens
-
 nicotinamide + [alpha-tubulin]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.286 Homo sapiens Q8IXJ6
-
-
2.3.1.286 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.286 brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.286 NAD+ + [alpha-tubulin]-N6-acyl-L-lysine
-
 Rattus norvegicus nicotinamide + [alpha-tubulin]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?
2.3.1.286 NAD+ + [alpha-tubulin]-N6-acyl-L-lysine
-
 Homo sapiens nicotinamide + [alpha-tubulin]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.286 ? x * 37000, SDS-PAGE Rattus norvegicus
2.3.1.286 ? x * 37000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.1.286 SIRT2
-
 Rattus norvegicus
2.3.1.286 SIRT2
-
 Homo sapiens