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Literature summary extracted from

  • Graindorge, M.; Giustini, C.; Kraut, A.; Moyet, L.; Curien, G.; Matringe, M.
    Three different classes of aminotransferases evolved prephenate aminotransferase functionality in arogenate-competent microorganisms (2014), J. Biol. Chem., 289, 3198-3208.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.1 0.017
-
 oxaloacetate pH 8.0, 30°C Sinorhizobium meliloti
2.6.1.17 0.021
-
 prephenate pH 8.0, 30°C Streptomyces avermitilis
2.6.1.42 0.045
-
 4-methyl-2-oxopentanoate pH 8.0, 30°C Synechocystis sp.
2.6.1.79 0.02
-
 prephenate cosubstrate L-glutamate, pH 8.0, 30°C Streptomyces avermitilis
2.6.1.79 0.021
-
 prephenate cosubstrate N-succinyl-L-2,6-diaminoheptanedioate, pH 8.0, 30°C Streptomyces avermitilis
2.6.1.79 0.1
-
 prephenate pH 8.0, 30°C Sinorhizobium meliloti
2.6.1.79 0.13
-
 prephenate pH 8.0, 30°C Synechocystis sp.

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.1 Sinorhizobium meliloti Q02635 bifunctional aspartate aminotransferase and aspartate:prephenate aminotransferase, EC 2.6.1.79
-
2.6.1.17 Streptomyces avermitilis Q82IK5 bifunctional diaminopimelate aminotransferase and aspartate:prephenate aminotransferase, EC 2.6.1.79
-
2.6.1.17 Streptomyces avermitilis DSM 46492 Q82IK5 bifunctional diaminopimelate aminotransferase and aspartate:prephenate aminotransferase, EC 2.6.1.79
-
2.6.1.42 Synechocystis sp. P54691 bifunctional branched-chain aminotransferase and aspartate:prephenate aminotransferase, EC 2.6.1.79
-
2.6.1.79 Sinorhizobium meliloti Q02635 cf. EC 2.6.1.1
-
2.6.1.79 Streptomyces avermitilis Q82IK5 cf. EC 2.6.1.17
-
2.6.1.79 Streptomyces avermitilis DSM 46492 Q82IK5 cf. EC 2.6.1.17
-
2.6.1.79 Synechocystis sp. P54691 cf. EC 2.6.1.42
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.1 oxaloacetate + L-glutamate
-
 Sinorhizobium meliloti L-aspartate + 2-oxoglutarate
-
 ?
2.6.1.17 prephenate + N-succinyl-L-2,6-diaminoheptanedioate
-
 Streptomyces avermitilis L-arogenate + N-succinyl-2-amino-6-oxoheptanedioate
-
 ?
2.6.1.17 prephenate + N-succinyl-L-2,6-diaminoheptanedioate
-
 Streptomyces avermitilis DSM 46492 L-arogenate + N-succinyl-2-amino-6-oxoheptanedioate
-
 ?
2.6.1.42 4-methyl-2-oxopentanoate + L-glutamate
-
 Synechocystis sp. L-leucine + 2-oxoglutarate
-
 ?
2.6.1.79 prephenate + L-glutamate
-
 Streptomyces avermitilis L-arogenate + 2-oxoglutarate
-
 ?
2.6.1.79 prephenate + L-glutamate
-
 Sinorhizobium meliloti L-arogenate + 2-oxoglutarate
-
 ?
2.6.1.79 prephenate + L-glutamate
-
 Synechocystis sp. L-arogenate + 2-oxoglutarate
-
 ?
2.6.1.79 prephenate + L-glutamate
-
 Streptomyces avermitilis DSM 46492 L-arogenate + 2-oxoglutarate
-
 ?
2.6.1.79 prephenate + N-succinyl-L-2,6-diaminoheptanedioate
-
 Streptomyces avermitilis L-arogenate + N-succinyl-2-amino-6-oxoheptanedioate
-
 ?
2.6.1.79 prephenate + N-succinyl-L-2,6-diaminoheptanedioate
-
 Streptomyces avermitilis DSM 46492 L-arogenate + N-succinyl-2-amino-6-oxoheptanedioate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.1 aatA
-
 Sinorhizobium meliloti
2.6.1.1 aspartate aminotransferase A
-
 Sinorhizobium meliloti
2.6.1.17 AspB2
-
 Streptomyces avermitilis
2.6.1.42 IlvE
-
 Synechocystis sp.
2.6.1.79 aatA
-
 Sinorhizobium meliloti
2.6.1.79 aspartate aminotransferase A
-
 Sinorhizobium meliloti
2.6.1.79 AspB2
-
 Streptomyces avermitilis
2.6.1.79 IlvE
-
 Synechocystis sp.

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.6.1.1 205
-
 oxaloacetate pH 8.0, 30°C Sinorhizobium meliloti
2.6.1.17 24
-
 prephenate pH 8.0, 30°C Streptomyces avermitilis
2.6.1.42 70
-
 4-methyl-2-oxopentanoate pH 8.0, 30°C Synechocystis sp.
2.6.1.79 24
-
 prephenate cosubstrate N-succinyl-L-2,6-diaminoheptanedioate, pH 8.0, 30°C Streptomyces avermitilis
2.6.1.79 43
-
 prephenate pH 8.0, 30°C Sinorhizobium meliloti
2.6.1.79 54
-
 prephenate cosubstrate L-glutamate, pH 8.0, 30°C Streptomyces avermitilis
2.6.1.79 60
-
 prephenate pH 8.0, 30°C Synechocystis sp.