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Literature summary extracted from

  • Adams, M.K.; Belyaeva, O.V.; Wu, L.; Kedishvili, N.Y.
    The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis (2014), J. Biol. Chem., 289, 14868-14880.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.105 retinoic acid-inducible dehydrogenase reductase 3
-
 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.105 expressed in HEK-293 cells and Sf9 insect cells Homo sapiens
1.1.1.105 expression in Sf9 cells, HepG2 and HEK293 cells Homo sapiens
1.1.1.300
-
 Mus musculus
1.1.1.300 expression in Sf9 cells, HepG2 and HEK293 cells Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.105 0.000039
-
 all-trans-retinol pH and temperature not specified in the publication Homo sapiens
1.1.1.105 0.000039
-
 all-trans-retinol pH not specified in the publication, temperature not specified in the publication Homo sapiens
1.1.1.105 0.00006
-
 11-cis-retinol pH and temperature not specified in the publication Homo sapiens
1.1.1.105 0.00046
-
 all-trans-retinaldehyde pH and temperature not specified in the publication Homo sapiens
1.1.1.105 0.00046
-
 all-trans retinal pH not specified in the publication, temperature not specified in the publication Homo sapiens
1.1.1.105 0.011
-
 NADH pH and temperature not specified in the publication Homo sapiens
1.1.1.105 0.011
-
 NADH pH not specified in the publication, temperature not specified in the publication Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.105 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.105 Homo sapiens
-
-
-
1.1.1.105 Homo sapiens Q8IZV5
-
-
1.1.1.300 Homo sapiens O75911
-
-
1.1.1.300 Mus musculus O88876
-
-
1.1.1.300 Mus musculus Q8VCH7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.105 11-cis-retinol + NAD+
-
 Homo sapiens ?
-
 ?
1.1.1.105 all-trans retinal + NADH + H+
-
 Homo sapiens all-trans-retinol + NAD+
-
 r
1.1.1.105 all-trans-retinaldehyde + NADH + H+
-
 Homo sapiens all-trans-retinol + NAD+
-
 r
1.1.1.105 all-trans-retinol + NAD+
-
 Homo sapiens all-trans-retinal + NADH + H+
-
 r
1.1.1.105 all-trans-retinol + NAD+
-
 Homo sapiens all-trans-retinaldehyde + NADH + H+
-
 r
1.1.1.105 additional information the enzyme is not active with NADP+ or NADPH as cofactors Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.105 RDH10
-
 Homo sapiens
1.1.1.105 retinol dehydrogenase 10
-
 Homo sapiens
1.1.1.300 DHRS3
-
 Homo sapiens
1.1.1.300 DHRS3
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.105 NAD+
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.1.1.105 physiological function the retinol dehydrogenase activity of RDH10 is activated by retinaldehyde reductase DHRS3. In turn, DHRS3 requires the presence of retinol dehydrogenase RDH10 to display its full catalytic activity. Neither RDH10 nor DHRS3 has to be itself catalytically active to activate each other Homo sapiens
1.1.1.300 physiological function DHRS3 activity requires the presence of retinol dehydrogenase RDH10 to display its full catalytic activity. The retinol dehydrogenase activity of RDH10 is reciprocally activated by retinaldehyde reductase DHRS3. At E13.5, DHRS3-null embryos have 4fold lower levels of retinol and retinyl esters, but only slightly elevated levels of retinoic acid. The membrane-associated retinaldehyde reductase and retinol dehydrogenase activities are decreased by 4- and 2fold, respectively, in Dhrs3-/- embryos, and Dhrs3-/- mouse embryonic fibroblasts exhibit reduced metabolism of both retinaldehyde andretinol. Neither RDH10 nor DHRS3 has to be itself catalytically active to activate each other Mus musculus
1.1.1.300 physiological function the retinol dehydrogenase activity of RDH10 is activated by retinaldehyde reductase DHRS3. In turn, DHRS3 requires the presence of retinol dehydrogenase RDH10 to display its full catalytic activity. Neither RDH10 nor DHRS3 has to be itself catalytically active to activate each other Homo sapiens
1.1.1.300 physiological function the retinol dehydrogenase activity of RDH10 is reciprocally activated by retinaldehyde reductase DHRS3. At E13.5, DHRS3-null embryos have 4fold lower levels of retinol and retinyl esters, but only slightly elevated levels of retinoic acid. The membrane-associated retinaldehyde reductase and retinol dehydrogenase activities are decreased by 4- and 2fold, respectively, in Dhrs3-/- embryos, and Dhrs3-/- mouse embryonic fibroblasts exhibit reduced metabolism of both retinaldehyde andretinol. Neither RDH10 nor DHRS3 has to be itself catalytically active to activate each other Mus musculus