Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Baba, S.P.; Hoetker, J.D.; Merchant, M.; Klein, J.B.; Cai, J.; Barski, O.A.; Conklin, D.J.; Bhatnagar, A.
    Role of aldose reductase in the metabolism and detoxification of carnosine-acrolein conjugates (2013), J. Biol. Chem., 288, 28163-28179.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.21 aldose + NADPH + H+ Homo sapiens
-
 alditol + NADP+
-
 ?
1.1.1.21 aldose + NADPH + H+ Mus musculus
-
 alditol + NADP+
-
 ?
1.1.1.21 additional information Mus musculus reduction of carnosine-propanal conjugates in murine tissues, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.21 Homo sapiens P15121
-
-
1.1.1.21 Mus musculus P45376
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.21 brain
-
 Homo sapiens
-
1.1.1.21 brain
-
 Mus musculus
-
1.1.1.21 heart
-
 Homo sapiens
-
1.1.1.21 heart
-
 Mus musculus
-
1.1.1.21 skeletal muscle
-
 Homo sapiens
-
1.1.1.21 skeletal muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.21 aldose + NADPH + H+
-
 Homo sapiens alditol + NADP+
-
 ?
1.1.1.21 aldose + NADPH + H+
-
 Mus musculus alditol + NADP+
-
 ?
1.1.1.21 additional information reduction of carnosine-propanal conjugates in murine tissues, overview Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.21 aldose reductase
-
 Homo sapiens
1.1.1.21 aldose reductase
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.21 37
-
 recombinant enzyme Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.21 6
-
 recombinant enzyme Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.21 NADPH
-
 Homo sapiens
1.1.1.21 NADPH
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.1.1.21 malfunction carnosine-propanals are converted to carnosine-propanols in the lysates of heart, skeletal muscle, and brain tissue from wild-type but not AR-null mice. In comparison with wild-type mice, the urinary excretion of carnosine-propanols is decreased in AR-null mice, overview Mus musculus
1.1.1.21 malfunction inhibition of AKR1B1 both prevents and reverses diabetic tissue injury that arises from the accumulation of sorbitol Homo sapiens
1.1.1.21 physiological function increased reduction of glucose to sorbitol under hyperglycemic conditions is implicated in tissue injury and the progression of a wide variety of diabetic complications, including neuropathy and retinopathy Homo sapiens
1.1.1.21 physiological function lipid peroxidation generates unsaturated aldehydes, such as acrolein, that form conjugates with histidyl dipeptides. Carnosine-aldehyde conjugates form covalent adducts with proteins and are reduced by aldose reductase. Detoxification of carnosine-aldehyde by aldose reductase prevents protein carnosinylation. Aldose reductase prevents tissue injury due to aldehyde-carnosine conjugates. Role of aldose reductase as a critical regulator of protein carnosinylation and carnosine-mediated tissue protection, overview Homo sapiens
1.1.1.21 physiological function lipid peroxidation generates unsaturated aldehydes, such as acrolein, that form conjugates with histidyl dipeptides.Carnosine-aldehyde conjugates form covalent adducts with proteins and are reduced by aldose reductase. Detoxification of carnosine-aldehyde by aldose reductase prevents protein carnosinylation. Aldose reductase prevents tissue injury due to aldehyde-carnosine conjugates. Carnosine-propanals are converted to carnosine-propanols in the lysates of heart, skeletal muscle, and brain tissue from wild-type but not AR-null mice. Role of aldose reductase as a critical regulator of protein carnosinylation and carnosine-mediated tissue protection, overview Mus musculus